Inhibition of Protein-Protein Interactions by Peptide Mimics

Jorge Becerril, Johanna M. Rodriguez, Pauline N. Wyrembak, Andrew Hamilton

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationProtein Surface Recognition: Approaches for Drug Discovery
PublisherJohn Wiley and Sons
Pages105-131
Number of pages27
ISBN (Print)9780470059050
DOIs
StatePublished - Nov 30 2010

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Peptides
Proteins

Keywords

  • β-sheet, second major structural element - in globular proteins
  • Biological processes, and communication between proteins - specific surface interactions
  • Coactivator proteins, multiple repeats - conserved Leu-X-X-Leu-Leu (LXXLL) motif
  • Inhibitors of protein-protein interactions - allies in fight against HIV-1 epidemic
  • Nuclear estrogen receptor inhibition
  • p53/MDM2 interaction, another protein-protein interaction - in apoptotic pathway
  • protein-protein interaction inhibition - by peptide mimics
  • Protein-protein interactions (PPIs) - normal cell function and regulating processes
  • Protein-protein interactions - mediated by binding epitope, residues as a-helix, β-turn or a β-sheet
  • Turns, common structural element - in PPIs, post-translational modifications and antibody recognition

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Becerril, J., Rodriguez, J. M., Wyrembak, P. N., & Hamilton, A. (2010). Inhibition of Protein-Protein Interactions by Peptide Mimics. In Protein Surface Recognition: Approaches for Drug Discovery (pp. 105-131). John Wiley and Sons. https://doi.org/10.1002/9780470972137.ch5

Inhibition of Protein-Protein Interactions by Peptide Mimics. / Becerril, Jorge; Rodriguez, Johanna M.; Wyrembak, Pauline N.; Hamilton, Andrew.

Protein Surface Recognition: Approaches for Drug Discovery. John Wiley and Sons, 2010. p. 105-131.

Research output: Chapter in Book/Report/Conference proceedingChapter

Becerril, J, Rodriguez, JM, Wyrembak, PN & Hamilton, A 2010, Inhibition of Protein-Protein Interactions by Peptide Mimics. in Protein Surface Recognition: Approaches for Drug Discovery. John Wiley and Sons, pp. 105-131. https://doi.org/10.1002/9780470972137.ch5
Becerril J, Rodriguez JM, Wyrembak PN, Hamilton A. Inhibition of Protein-Protein Interactions by Peptide Mimics. In Protein Surface Recognition: Approaches for Drug Discovery. John Wiley and Sons. 2010. p. 105-131 https://doi.org/10.1002/9780470972137.ch5
Becerril, Jorge ; Rodriguez, Johanna M. ; Wyrembak, Pauline N. ; Hamilton, Andrew. / Inhibition of Protein-Protein Interactions by Peptide Mimics. Protein Surface Recognition: Approaches for Drug Discovery. John Wiley and Sons, 2010. pp. 105-131
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