Abstract
Apolipoprotein E (APOE) polymorphism plays an important role in lipid metabolism. Preliminary evidence suggests that APOE genotype appears to be a risk factor for not only cardiovascular disease, but also Alzheimer's disease and cancer. We screened the APOE genotype in 290 breast cancer patients and 232 non-cancer controls and determined the relationship between APOE gene polymorphism and breast cancer in Taiwan. We found risk for breast cancer was associated with the APOE genotype (ξ2 = 8.652, p = 0.013). Carriers of the ε4 allele were more common in breast cancer cases than carriers of ε3 allele (p = 0.004, OR = 1.786, 95% CI: 1.197-2.664). In addition, the ε4 allele is also associated with HER2/neu negative status in breast cancer patients (p = 0.006, OR = 0.277, 95% CI: 0.111-0.693). No significant associations between APOE genotype and tumor grade, TN classification, progesterone receptor, estrogen receptor, lymphatic invasion, or recurrence of breast cancer were in evidence. These results suggest that the APOE ε4 allele may be a risk factor for breast cancer and correlates with HER2/neu negative status.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 257-261 |
| Number of pages | 5 |
| Journal | Breast Cancer Research and Treatment |
| Volume | 90 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 2005 |
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Keywords
- Apolipoprotein E polymorphism
- Breast cancer
- HER2/neu
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan. / Chang, Nai Wen; Chen, Dar Ren; Wu, Chen Ten; Aouizerat, Bradley E.; Chen, Fei Na; Hung, Shin Jer; Wang, Shiuan Huei; Wei, Ming Feng; Chang, Cheng Shyong.
In: Breast Cancer Research and Treatment, Vol. 90, No. 3, 04.2005, p. 257-261.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan
AU - Chang, Nai Wen
AU - Chen, Dar Ren
AU - Wu, Chen Ten
AU - Aouizerat, Bradley E.
AU - Chen, Fei Na
AU - Hung, Shin Jer
AU - Wang, Shiuan Huei
AU - Wei, Ming Feng
AU - Chang, Cheng Shyong
PY - 2005/4
Y1 - 2005/4
N2 - Apolipoprotein E (APOE) polymorphism plays an important role in lipid metabolism. Preliminary evidence suggests that APOE genotype appears to be a risk factor for not only cardiovascular disease, but also Alzheimer's disease and cancer. We screened the APOE genotype in 290 breast cancer patients and 232 non-cancer controls and determined the relationship between APOE gene polymorphism and breast cancer in Taiwan. We found risk for breast cancer was associated with the APOE genotype (ξ2 = 8.652, p = 0.013). Carriers of the ε4 allele were more common in breast cancer cases than carriers of ε3 allele (p = 0.004, OR = 1.786, 95% CI: 1.197-2.664). In addition, the ε4 allele is also associated with HER2/neu negative status in breast cancer patients (p = 0.006, OR = 0.277, 95% CI: 0.111-0.693). No significant associations between APOE genotype and tumor grade, TN classification, progesterone receptor, estrogen receptor, lymphatic invasion, or recurrence of breast cancer were in evidence. These results suggest that the APOE ε4 allele may be a risk factor for breast cancer and correlates with HER2/neu negative status.
AB - Apolipoprotein E (APOE) polymorphism plays an important role in lipid metabolism. Preliminary evidence suggests that APOE genotype appears to be a risk factor for not only cardiovascular disease, but also Alzheimer's disease and cancer. We screened the APOE genotype in 290 breast cancer patients and 232 non-cancer controls and determined the relationship between APOE gene polymorphism and breast cancer in Taiwan. We found risk for breast cancer was associated with the APOE genotype (ξ2 = 8.652, p = 0.013). Carriers of the ε4 allele were more common in breast cancer cases than carriers of ε3 allele (p = 0.004, OR = 1.786, 95% CI: 1.197-2.664). In addition, the ε4 allele is also associated with HER2/neu negative status in breast cancer patients (p = 0.006, OR = 0.277, 95% CI: 0.111-0.693). No significant associations between APOE genotype and tumor grade, TN classification, progesterone receptor, estrogen receptor, lymphatic invasion, or recurrence of breast cancer were in evidence. These results suggest that the APOE ε4 allele may be a risk factor for breast cancer and correlates with HER2/neu negative status.
KW - Apolipoprotein E polymorphism
KW - Breast cancer
KW - HER2/neu
UR - http://www.scopus.com/inward/record.url?scp=17744379364&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17744379364&partnerID=8YFLogxK
U2 - 10.1007/s10549-004-4656-7
DO - 10.1007/s10549-004-4656-7
M3 - Article
VL - 90
SP - 257
EP - 261
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 3
ER -