Influence of estrogen deficiency on bone around osseointegrated dental implants: An experimental study in the rat jaw model

Gabriela Giro, Paulo Coelho, Roberto Sales-Pessoa, Rosa Maria Rodrigues Pereira, Toshihisa Kawai, Silvana Regina Perez Orrico

Research output: Contribution to journalArticle

Abstract

Purpose: The aim of this study was to evaluate the influence of estrogen deficiency on bone around osseointegrated dental implants in a rat jaw model. Materials and Methods: This study used 16 female rats that had the first molars bilaterally extracted and were allowed to heal for 30 days before implant placement. Sixty days after implant placement, the animals were randomly subjected to sham surgery or ovariectomy (OVX). The animals were euthanized 90 days after OVX. Bone-to-implant contact, bone area fraction occupancy between implant threads, mineral density, turnover markers, and cells positive for tartrate-resistant acid phosphatase were assessed for the 2 groups. Results: The results showed that OVX group presented a decrease of systemic bone density, alterations in bone turnover markers, and an increase of cells positive for tartrate-resistant acid phosphatase compared with the sham-surgery group. However, no difference relative to bone-to-implant contact and bone area fraction occupancy was observed between groups. Conclusions: The findings of this study demonstrate that estrogen deficiency may not be considered a risk factor for osseointegrated implant failure in jaw bone.

Original languageEnglish (US)
Pages (from-to)1911-1918
Number of pages8
JournalJournal of Oral and Maxillofacial Surgery
Volume69
Issue number7
DOIs
StatePublished - Jul 2011

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Dental Implants
Jaw
Estrogens
Bone and Bones
Bone Remodeling
Ovariectomy
Bone Density
Minerals

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology
  • Surgery

Cite this

Influence of estrogen deficiency on bone around osseointegrated dental implants : An experimental study in the rat jaw model. / Giro, Gabriela; Coelho, Paulo; Sales-Pessoa, Roberto; Rodrigues Pereira, Rosa Maria; Kawai, Toshihisa; Perez Orrico, Silvana Regina.

In: Journal of Oral and Maxillofacial Surgery, Vol. 69, No. 7, 07.2011, p. 1911-1918.

Research output: Contribution to journalArticle

Giro, Gabriela ; Coelho, Paulo ; Sales-Pessoa, Roberto ; Rodrigues Pereira, Rosa Maria ; Kawai, Toshihisa ; Perez Orrico, Silvana Regina. / Influence of estrogen deficiency on bone around osseointegrated dental implants : An experimental study in the rat jaw model. In: Journal of Oral and Maxillofacial Surgery. 2011 ; Vol. 69, No. 7. pp. 1911-1918.
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