Influence of dendritic conductances on the input-output properties of neurons

Research output: Contribution to journalArticle

Abstract

A fundamental problem in neuroscience is understanding how a neuron transduces synaptic input into action potentials. The dendrites form the substrate for consolidating thousands of synaptic inputs and are the first stage for signal processing in the neuron. Traditionally, dendrites are viewed as passive structures whose main function is to funnel synaptic input into the soma. However, dendrites contain a wide variety of voltage- and time-dependent ion channels. When activated, the currents through these channels can alter the amplitude and time course of the synaptic input and under certain conditions even evoke all-or-none regenerative potentials. The synaptic input that ultimately reaches the soma is likely to be a highly transformed version of the original signal. Thus, a key step in understanding the relationship between synaptic input and neuronal firing is to elucidate the signal processing that occurs in the dendrites.

Original languageEnglish (US)
Pages (from-to)653-675
Number of pages23
JournalAnnual Review of Neuroscience
Volume24
DOIs
StatePublished - 2001

Fingerprint

Dendrites
Neurons
Carisoprodol
Neurosciences
Ion Channels
Action Potentials

Keywords

  • Channels
  • Conductance
  • Dendrite
  • Firing
  • Integration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Influence of dendritic conductances on the input-output properties of neurons. / Reyes, Alexander.

In: Annual Review of Neuroscience, Vol. 24, 2001, p. 653-675.

Research output: Contribution to journalArticle

@article{e4e25e8e36814468b318fe11dc31cd8a,
title = "Influence of dendritic conductances on the input-output properties of neurons",
abstract = "A fundamental problem in neuroscience is understanding how a neuron transduces synaptic input into action potentials. The dendrites form the substrate for consolidating thousands of synaptic inputs and are the first stage for signal processing in the neuron. Traditionally, dendrites are viewed as passive structures whose main function is to funnel synaptic input into the soma. However, dendrites contain a wide variety of voltage- and time-dependent ion channels. When activated, the currents through these channels can alter the amplitude and time course of the synaptic input and under certain conditions even evoke all-or-none regenerative potentials. The synaptic input that ultimately reaches the soma is likely to be a highly transformed version of the original signal. Thus, a key step in understanding the relationship between synaptic input and neuronal firing is to elucidate the signal processing that occurs in the dendrites.",
keywords = "Channels, Conductance, Dendrite, Firing, Integration",
author = "Alexander Reyes",
year = "2001",
doi = "10.1146/annurev.neuro.24.1.653",
language = "English (US)",
volume = "24",
pages = "653--675",
journal = "Annual Review of Neuroscience",
issn = "0147-006X",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Influence of dendritic conductances on the input-output properties of neurons

AU - Reyes, Alexander

PY - 2001

Y1 - 2001

N2 - A fundamental problem in neuroscience is understanding how a neuron transduces synaptic input into action potentials. The dendrites form the substrate for consolidating thousands of synaptic inputs and are the first stage for signal processing in the neuron. Traditionally, dendrites are viewed as passive structures whose main function is to funnel synaptic input into the soma. However, dendrites contain a wide variety of voltage- and time-dependent ion channels. When activated, the currents through these channels can alter the amplitude and time course of the synaptic input and under certain conditions even evoke all-or-none regenerative potentials. The synaptic input that ultimately reaches the soma is likely to be a highly transformed version of the original signal. Thus, a key step in understanding the relationship between synaptic input and neuronal firing is to elucidate the signal processing that occurs in the dendrites.

AB - A fundamental problem in neuroscience is understanding how a neuron transduces synaptic input into action potentials. The dendrites form the substrate for consolidating thousands of synaptic inputs and are the first stage for signal processing in the neuron. Traditionally, dendrites are viewed as passive structures whose main function is to funnel synaptic input into the soma. However, dendrites contain a wide variety of voltage- and time-dependent ion channels. When activated, the currents through these channels can alter the amplitude and time course of the synaptic input and under certain conditions even evoke all-or-none regenerative potentials. The synaptic input that ultimately reaches the soma is likely to be a highly transformed version of the original signal. Thus, a key step in understanding the relationship between synaptic input and neuronal firing is to elucidate the signal processing that occurs in the dendrites.

KW - Channels

KW - Conductance

KW - Dendrite

KW - Firing

KW - Integration

UR - http://www.scopus.com/inward/record.url?scp=0034920695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034920695&partnerID=8YFLogxK

U2 - 10.1146/annurev.neuro.24.1.653

DO - 10.1146/annurev.neuro.24.1.653

M3 - Article

VL - 24

SP - 653

EP - 675

JO - Annual Review of Neuroscience

JF - Annual Review of Neuroscience

SN - 0147-006X

ER -