Infantile amnesia reflects a developmental critical period for hippocampal learning

Alessio Travaglia, Reto Bisaz, Eric S. Sweet, Robert D. Blitzer, Cristina Alberini

Research output: Contribution to journalArticle

Abstract

Episodic memories formed during the first postnatal period are rapidly forgotten, a phenomenon known as 'infantile amnesia'. In spite of this memory loss, early experiences influence adult behavior, raising the question of which mechanisms underlie infantile memories and amnesia. Here we show that in rats an experience learned during the infantile amnesia period is stored as a latent memory trace for a long time; indeed, a later reminder reinstates a robust, context-specific and long-lasting memory. The formation and storage of this latent memory requires the hippocampus, follows a sharp temporal boundary and occurs through mechanisms typical of developmental critical periods, including the expression switch of the NMDA receptor subunits from 2B to 2A, which is dependent on brain-derived neurotrophic factor (BDNF) and metabotropic glutamate receptor 5 (mGluR5). Activating BDNF or mGluR5 after training rescues the infantile amnesia. Thus, early episodic memories are not lost but remain stored long term. These data suggest that the hippocampus undergoes a developmental critical period to become functionally competent.

Original languageEnglish (US)
JournalNature Neuroscience
DOIs
StateAccepted/In press - Jul 18 2016

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Amnesia
Metabotropic Glutamate 5 Receptor
Learning
Episodic Memory
Brain-Derived Neurotrophic Factor
Hippocampus
Memory Disorders
Critical Period (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Infantile amnesia reflects a developmental critical period for hippocampal learning. / Travaglia, Alessio; Bisaz, Reto; Sweet, Eric S.; Blitzer, Robert D.; Alberini, Cristina.

In: Nature Neuroscience, 18.07.2016.

Research output: Contribution to journalArticle

Travaglia, Alessio ; Bisaz, Reto ; Sweet, Eric S. ; Blitzer, Robert D. ; Alberini, Cristina. / Infantile amnesia reflects a developmental critical period for hippocampal learning. In: Nature Neuroscience. 2016.
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