Infantile amnesia: A critical period of learning to learn and remember

Cristina Alberini, Alessio Travaglia

Research output: Contribution to journalArticle

Abstract

Infantile amnesia, the inability of adults to recollect early episodic memories, is associated with the rapid forgetting that occurs in childhood. It has been suggested that infantile amnesia is due to the underdevelopment of the infant brain, which would preclude memory consolidation, or to deficits in memory retrieval. Although early memories are inaccessible to adults, early-life events, such as neglect or aversive experiences, can greatly impact adult behavior and may predispose individuals to various psychopathologies. It remains unclear how a brain that rapidly forgets, or is not yet able to form long-term memories, can exert such a long-lasting and important influence. Here, with a particular focus on the hippocampal memory system, we review the literature and discuss new evidence obtained in rats that illuminates the paradox of infantile amnesia. We propose that infantile amnesia reflects a developmental critical period during which the learning system is learning how to learn and remember.

Original languageEnglish (US)
Pages (from-to)5783-5795
Number of pages13
JournalJournal of Neuroscience
Volume37
Issue number24
DOIs
StatePublished - Jun 14 2017

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Amnesia
Learning
Episodic Memory
Long-Term Memory
Memory Disorders
Brain
Psychopathology
Critical Period (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Infantile amnesia : A critical period of learning to learn and remember. / Alberini, Cristina; Travaglia, Alessio.

In: Journal of Neuroscience, Vol. 37, No. 24, 14.06.2017, p. 5783-5795.

Research output: Contribution to journalArticle

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