Infant cerebral ventricle volume

a comparison of 3-D ultrasound and magnetic resonance imaging

John H. Gilmore, Guido Gerig, Barbara Specter, H. Cecil Charles, Joseph S. Wilber, Barbara S. Hertzberg, Mark A. Kliewer

    Research output: Contribution to journalArticle

    Abstract

    Enlargement of the cerebral lateral ventricles is observed in several neuropsychiatric disorders with origins in early brain development. Lateral ventricle size is also predictive of poor neurodevelopmental outcome in premature infants. Three-dimensional (3-D) ultrasound (US) offers an improved methodology for the study of lateral ventricle volume in neonates and infants. To assess the validity of ventricle volume measures obtained with 3-D US, we compared the volumes obtained by 3-D US with magnetic resonance imaging (MRI) in seven infants. Ventricle volumes were determined using a computer-assisted image analysis program, IRIS. There was excellent correlation between ventricle volumes obtained with 3-D US and those obtained with MRI (intraclass correlation coefficient 0.92, F = 23.28, p = 0.00027), indicating that 3-D US provides valid measures of overall lateral ventricle volume compared to the 'gold standard' of MRI. 3-D US can provide an economical and practical means of studying lateral ventricle volume in neonates, a neurostructural marker of abnormal brain development.

    Original languageEnglish (US)
    Pages (from-to)1143-1146
    Number of pages4
    JournalUltrasound in Medicine and Biology
    Volume27
    Issue number8
    DOIs
    StatePublished - 2001

    Fingerprint

    cerebral ventricles
    Cerebral Ventricles
    Lateral Ventricles
    magnetic resonance
    Magnetic Resonance Imaging
    Newborn Infant
    brain
    Computer-Assisted Image Processing
    Brain
    Premature Infants
    image analysis
    correlation coefficients
    markers
    disorders
    methodology

    Keywords

    • Computer-assisted image analysis
    • Lateral ventricle
    • Magnetic resonance imaging
    • Neurodevelopmental disorders
    • Premature infants
    • Three-dimensional ultrasound

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Cite this

    Gilmore, J. H., Gerig, G., Specter, B., Charles, H. C., Wilber, J. S., Hertzberg, B. S., & Kliewer, M. A. (2001). Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging. Ultrasound in Medicine and Biology, 27(8), 1143-1146. https://doi.org/10.1016/S0301-5629(01)00400-8

    Infant cerebral ventricle volume : a comparison of 3-D ultrasound and magnetic resonance imaging. / Gilmore, John H.; Gerig, Guido; Specter, Barbara; Charles, H. Cecil; Wilber, Joseph S.; Hertzberg, Barbara S.; Kliewer, Mark A.

    In: Ultrasound in Medicine and Biology, Vol. 27, No. 8, 2001, p. 1143-1146.

    Research output: Contribution to journalArticle

    Gilmore, JH, Gerig, G, Specter, B, Charles, HC, Wilber, JS, Hertzberg, BS & Kliewer, MA 2001, 'Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging', Ultrasound in Medicine and Biology, vol. 27, no. 8, pp. 1143-1146. https://doi.org/10.1016/S0301-5629(01)00400-8
    Gilmore, John H. ; Gerig, Guido ; Specter, Barbara ; Charles, H. Cecil ; Wilber, Joseph S. ; Hertzberg, Barbara S. ; Kliewer, Mark A. / Infant cerebral ventricle volume : a comparison of 3-D ultrasound and magnetic resonance imaging. In: Ultrasound in Medicine and Biology. 2001 ; Vol. 27, No. 8. pp. 1143-1146.
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