Induction of the neural crest and the opportunities of life on the edge

Research output: Contribution to journalArticle

Abstract

The neural crest is a multipotent population of migratory cells unique to the vertebrate embryo. Neural crest arises at the lateral edge of the neural plate and migrates throughout the embryo to give rise to a wide variety of cell types including peripheral and enteric neurons and glia, craniofacial cartilage and bone, smooth muscle, and pigment cells. Here we review recent studies that have addressed the role of several signaling pathways in the induction of the neural crest. Work in the mouse, chick, Xenopus, and zebrafish have shown that a complex network of genes is activated at the neural plate border in response to neural crest-inducing signals. We also summarize some of these findings and discuss how the differential activation of these genes may contribute to the establishment of neural crest diversity.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalDevelopmental Biology
Volume275
Issue number1
DOIs
StatePublished - Nov 1 2004

Fingerprint

Neural Crest
Neural Plate
Embryonic Structures
Gene Regulatory Networks
Zebrafish
Xenopus
Neuroglia
Transcriptional Activation
Cartilage
Smooth Muscle Myocytes
Vertebrates
Neurons
Bone and Bones
Population

Keywords

  • Bmp
  • Fgf
  • Induction
  • Neural crest
  • Notch/Delta
  • Transcriptional regulators
  • Wnt

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Induction of the neural crest and the opportunities of life on the edge. / Huang, Xiao; Saint-Jeannet, Jean-Pierre.

In: Developmental Biology, Vol. 275, No. 1, 01.11.2004, p. 1-11.

Research output: Contribution to journalArticle

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