Induction and Specification of Neural Crest Cells: Extracellular Signals and Transcriptional Switches

Research output: Chapter in Book/Report/Conference proceedingChapter


The neural crest is a multipotent population of migratory cells unique to the vertebrate embryo. Neural crest cells form at the neural plate border during gastrulation and, around the time of neural tube closure, leave the neuroepithelium to produce a diverse array of cell types, contributing to multiple organ systems. Neural crest cells are generated through a sequence of events orchestrated by the modulation of several signaling pathways and the activation of a complex network of transcription factors. Here, we review recent advances in the characterization of the molecular players directing neural crest induction and specification, comparing data from different model organisms.

Original languageEnglish (US)
Title of host publicationNeural Crest Cells
Subtitle of host publicationEvolution, Development and Disease
PublisherElsevier Inc.
Number of pages23
ISBN (Print)9780124017306
StatePublished - Jan 1 2014



  • Bmp
  • Fgf
  • Gene regulatory network
  • Neural crest
  • Wnt

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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