Individual differences in fear

Isolating fear reactivity and fear recovery phenotypes

David E A Bush, Francisco Sotres-Bayon, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

Although different people respond differently to threatening events, animal research on the neural basis of fear tends to focus on typical responses. Yet there are substantial individual differences between animals exposed to identical behavioral procedures. In an effort to begin to understand the nature and causes of fear variability and resilience, we separated outbred Sprague-Dawley rats into high and low reactivity, and fast and slow recovery phenotypes, based on freezing levels during fear conditioning and extinction, respectively. Subsequent tests revealed stable differences in both measures, indicating that fear responses reflect trait-like phenotypes in outbred animals. Because clinical disorders may reflect extreme phenotypes, identification of the biological basis for these differences could provide insights into human individual differences in fear.

Original languageEnglish (US)
Pages (from-to)413-422
Number of pages10
JournalJournal of Traumatic Stress
Volume20
Issue number4
DOIs
StatePublished - Aug 2007

Fingerprint

Individuality
Fear
Phenotype
Freezing
Sprague Dawley Rats

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Individual differences in fear : Isolating fear reactivity and fear recovery phenotypes. / Bush, David E A; Sotres-Bayon, Francisco; Ledoux, Joseph.

In: Journal of Traumatic Stress, Vol. 20, No. 4, 08.2007, p. 413-422.

Research output: Contribution to journalArticle

Bush, David E A ; Sotres-Bayon, Francisco ; Ledoux, Joseph. / Individual differences in fear : Isolating fear reactivity and fear recovery phenotypes. In: Journal of Traumatic Stress. 2007 ; Vol. 20, No. 4. pp. 413-422.
@article{5c63687a68c44296a9f65c5493ccce04,
title = "Individual differences in fear: Isolating fear reactivity and fear recovery phenotypes",
abstract = "Although different people respond differently to threatening events, animal research on the neural basis of fear tends to focus on typical responses. Yet there are substantial individual differences between animals exposed to identical behavioral procedures. In an effort to begin to understand the nature and causes of fear variability and resilience, we separated outbred Sprague-Dawley rats into high and low reactivity, and fast and slow recovery phenotypes, based on freezing levels during fear conditioning and extinction, respectively. Subsequent tests revealed stable differences in both measures, indicating that fear responses reflect trait-like phenotypes in outbred animals. Because clinical disorders may reflect extreme phenotypes, identification of the biological basis for these differences could provide insights into human individual differences in fear.",
author = "Bush, {David E A} and Francisco Sotres-Bayon and Joseph Ledoux",
year = "2007",
month = "8",
doi = "10.1002/jts.20261",
language = "English (US)",
volume = "20",
pages = "413--422",
journal = "Journal of Traumatic Stress",
issn = "0894-9867",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Individual differences in fear

T2 - Isolating fear reactivity and fear recovery phenotypes

AU - Bush, David E A

AU - Sotres-Bayon, Francisco

AU - Ledoux, Joseph

PY - 2007/8

Y1 - 2007/8

N2 - Although different people respond differently to threatening events, animal research on the neural basis of fear tends to focus on typical responses. Yet there are substantial individual differences between animals exposed to identical behavioral procedures. In an effort to begin to understand the nature and causes of fear variability and resilience, we separated outbred Sprague-Dawley rats into high and low reactivity, and fast and slow recovery phenotypes, based on freezing levels during fear conditioning and extinction, respectively. Subsequent tests revealed stable differences in both measures, indicating that fear responses reflect trait-like phenotypes in outbred animals. Because clinical disorders may reflect extreme phenotypes, identification of the biological basis for these differences could provide insights into human individual differences in fear.

AB - Although different people respond differently to threatening events, animal research on the neural basis of fear tends to focus on typical responses. Yet there are substantial individual differences between animals exposed to identical behavioral procedures. In an effort to begin to understand the nature and causes of fear variability and resilience, we separated outbred Sprague-Dawley rats into high and low reactivity, and fast and slow recovery phenotypes, based on freezing levels during fear conditioning and extinction, respectively. Subsequent tests revealed stable differences in both measures, indicating that fear responses reflect trait-like phenotypes in outbred animals. Because clinical disorders may reflect extreme phenotypes, identification of the biological basis for these differences could provide insights into human individual differences in fear.

UR - http://www.scopus.com/inward/record.url?scp=34748913575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34748913575&partnerID=8YFLogxK

U2 - 10.1002/jts.20261

DO - 10.1002/jts.20261

M3 - Article

VL - 20

SP - 413

EP - 422

JO - Journal of Traumatic Stress

JF - Journal of Traumatic Stress

SN - 0894-9867

IS - 4

ER -