Increased tumor growth in mice with diet-induced obesity: Impact of ovarian hormones

Shoshana Yakar, Nomeli P. Nunez, Patricia Pennisi, Pnina Brodt, Hui Sun, Lucia Fallavollita, Hong Zhao, Louis Scavo, Ruslan Novosyadlyy, Naamit Kurshan, Bethel Stannard, Joyce East-Palmer, Nicole C P Smith, Susan N. Perkins, Robin Fuchs-Young, J. Carl Barrett, Stephen D. Hursting, Derek LeRoith

Research output: Contribution to journalArticle

Abstract

Obesity increases the risk of many cancers in both males and females. This study describes a link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer in male and female mice. The goal of this study was to evaluate the relationship between gender and obesity and to determine the role of estrogen status in obese females and its effect on tumor growth. We examined the susceptibility of C57BL/6 mice to diet-induced obesity, insulin resistance/glucose intolerance, and tumors. Mice were injected sc with one of two tumorigenic cell lines, Lewis lung carcinoma, or mouse colon 38-adenocarcinoma. Results show that tumor growth rate was increased in obese mice vs. control mice irrespective of the tumor cell type. To investigate the effect of estrogen status on tumor development in obese females, we compared metabolic parameters and tumor growth in ovariectomized (ovx) and intact obese female mice. Obese ovx female mice developed insulin resistance and glucose intolerance similar to that observed in obese males. Our results demonstrate that body adiposity increased in ovx females irrespective of the diet administered and that tumor growth correlated positively with body adiposity. Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice.

Original languageEnglish (US)
Pages (from-to)5826-5834
Number of pages9
JournalEndocrinology
Volume147
Issue number12
DOIs
StatePublished - 2006

Fingerprint

Obesity
Hormones
Diet
Growth
Neoplasms
Obese Mice
Adiposity
Insulin Resistance
Glucose Intolerance
Estrogens
Lewis Lung Carcinoma
Inbred C57BL Mouse
Colon
Adenocarcinoma
Steroids
Cell Line

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Yakar, S., Nunez, N. P., Pennisi, P., Brodt, P., Sun, H., Fallavollita, L., ... LeRoith, D. (2006). Increased tumor growth in mice with diet-induced obesity: Impact of ovarian hormones. Endocrinology, 147(12), 5826-5834. https://doi.org/10.1210/en.2006-0311

Increased tumor growth in mice with diet-induced obesity : Impact of ovarian hormones. / Yakar, Shoshana; Nunez, Nomeli P.; Pennisi, Patricia; Brodt, Pnina; Sun, Hui; Fallavollita, Lucia; Zhao, Hong; Scavo, Louis; Novosyadlyy, Ruslan; Kurshan, Naamit; Stannard, Bethel; East-Palmer, Joyce; Smith, Nicole C P; Perkins, Susan N.; Fuchs-Young, Robin; Barrett, J. Carl; Hursting, Stephen D.; LeRoith, Derek.

In: Endocrinology, Vol. 147, No. 12, 2006, p. 5826-5834.

Research output: Contribution to journalArticle

Yakar, S, Nunez, NP, Pennisi, P, Brodt, P, Sun, H, Fallavollita, L, Zhao, H, Scavo, L, Novosyadlyy, R, Kurshan, N, Stannard, B, East-Palmer, J, Smith, NCP, Perkins, SN, Fuchs-Young, R, Barrett, JC, Hursting, SD & LeRoith, D 2006, 'Increased tumor growth in mice with diet-induced obesity: Impact of ovarian hormones', Endocrinology, vol. 147, no. 12, pp. 5826-5834. https://doi.org/10.1210/en.2006-0311
Yakar, Shoshana ; Nunez, Nomeli P. ; Pennisi, Patricia ; Brodt, Pnina ; Sun, Hui ; Fallavollita, Lucia ; Zhao, Hong ; Scavo, Louis ; Novosyadlyy, Ruslan ; Kurshan, Naamit ; Stannard, Bethel ; East-Palmer, Joyce ; Smith, Nicole C P ; Perkins, Susan N. ; Fuchs-Young, Robin ; Barrett, J. Carl ; Hursting, Stephen D. ; LeRoith, Derek. / Increased tumor growth in mice with diet-induced obesity : Impact of ovarian hormones. In: Endocrinology. 2006 ; Vol. 147, No. 12. pp. 5826-5834.
@article{306e1885b2e544c59af628aa2d9a988a,
title = "Increased tumor growth in mice with diet-induced obesity: Impact of ovarian hormones",
abstract = "Obesity increases the risk of many cancers in both males and females. This study describes a link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer in male and female mice. The goal of this study was to evaluate the relationship between gender and obesity and to determine the role of estrogen status in obese females and its effect on tumor growth. We examined the susceptibility of C57BL/6 mice to diet-induced obesity, insulin resistance/glucose intolerance, and tumors. Mice were injected sc with one of two tumorigenic cell lines, Lewis lung carcinoma, or mouse colon 38-adenocarcinoma. Results show that tumor growth rate was increased in obese mice vs. control mice irrespective of the tumor cell type. To investigate the effect of estrogen status on tumor development in obese females, we compared metabolic parameters and tumor growth in ovariectomized (ovx) and intact obese female mice. Obese ovx female mice developed insulin resistance and glucose intolerance similar to that observed in obese males. Our results demonstrate that body adiposity increased in ovx females irrespective of the diet administered and that tumor growth correlated positively with body adiposity. Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice.",
author = "Shoshana Yakar and Nunez, {Nomeli P.} and Patricia Pennisi and Pnina Brodt and Hui Sun and Lucia Fallavollita and Hong Zhao and Louis Scavo and Ruslan Novosyadlyy and Naamit Kurshan and Bethel Stannard and Joyce East-Palmer and Smith, {Nicole C P} and Perkins, {Susan N.} and Robin Fuchs-Young and Barrett, {J. Carl} and Hursting, {Stephen D.} and Derek LeRoith",
year = "2006",
doi = "10.1210/en.2006-0311",
language = "English (US)",
volume = "147",
pages = "5826--5834",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "12",

}

TY - JOUR

T1 - Increased tumor growth in mice with diet-induced obesity

T2 - Impact of ovarian hormones

AU - Yakar, Shoshana

AU - Nunez, Nomeli P.

AU - Pennisi, Patricia

AU - Brodt, Pnina

AU - Sun, Hui

AU - Fallavollita, Lucia

AU - Zhao, Hong

AU - Scavo, Louis

AU - Novosyadlyy, Ruslan

AU - Kurshan, Naamit

AU - Stannard, Bethel

AU - East-Palmer, Joyce

AU - Smith, Nicole C P

AU - Perkins, Susan N.

AU - Fuchs-Young, Robin

AU - Barrett, J. Carl

AU - Hursting, Stephen D.

AU - LeRoith, Derek

PY - 2006

Y1 - 2006

N2 - Obesity increases the risk of many cancers in both males and females. This study describes a link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer in male and female mice. The goal of this study was to evaluate the relationship between gender and obesity and to determine the role of estrogen status in obese females and its effect on tumor growth. We examined the susceptibility of C57BL/6 mice to diet-induced obesity, insulin resistance/glucose intolerance, and tumors. Mice were injected sc with one of two tumorigenic cell lines, Lewis lung carcinoma, or mouse colon 38-adenocarcinoma. Results show that tumor growth rate was increased in obese mice vs. control mice irrespective of the tumor cell type. To investigate the effect of estrogen status on tumor development in obese females, we compared metabolic parameters and tumor growth in ovariectomized (ovx) and intact obese female mice. Obese ovx female mice developed insulin resistance and glucose intolerance similar to that observed in obese males. Our results demonstrate that body adiposity increased in ovx females irrespective of the diet administered and that tumor growth correlated positively with body adiposity. Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice.

AB - Obesity increases the risk of many cancers in both males and females. This study describes a link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer in male and female mice. The goal of this study was to evaluate the relationship between gender and obesity and to determine the role of estrogen status in obese females and its effect on tumor growth. We examined the susceptibility of C57BL/6 mice to diet-induced obesity, insulin resistance/glucose intolerance, and tumors. Mice were injected sc with one of two tumorigenic cell lines, Lewis lung carcinoma, or mouse colon 38-adenocarcinoma. Results show that tumor growth rate was increased in obese mice vs. control mice irrespective of the tumor cell type. To investigate the effect of estrogen status on tumor development in obese females, we compared metabolic parameters and tumor growth in ovariectomized (ovx) and intact obese female mice. Obese ovx female mice developed insulin resistance and glucose intolerance similar to that observed in obese males. Our results demonstrate that body adiposity increased in ovx females irrespective of the diet administered and that tumor growth correlated positively with body adiposity. Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice.

UR - http://www.scopus.com/inward/record.url?scp=33751509395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751509395&partnerID=8YFLogxK

U2 - 10.1210/en.2006-0311

DO - 10.1210/en.2006-0311

M3 - Article

VL - 147

SP - 5826

EP - 5834

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 12

ER -