Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors

Efrain C. Azmitia, Jorawer S. Singh, Patricia M. Whitaker-Azmitia

Research output: Contribution to journalArticle

Abstract

Imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. However, treatment with drugs which increase serotonin (5-HT) levels, specific serotonin reuptake inhibitors (SSRIs), commonly produce a worsening of the symptoms. In this study we examined 5-HT axons that were immunoreactive to a serotonin transporter (5-HTT) antibody in a number of postmortem brains from autistic patients and controls with no known diagnosis who ranged in age from 2 to 29 years. Fine, highly branched, and thick straight fibers were found in forebrain pathways (e.g. medial forebrain bundle, stria terminalis and ansa lenticularis). Many immunoreactive varicose fine fibers were seen in target areas (e.g. globus pallidus, amygdala and temporal cortex). Morphometric analysis of the stained axons at all ages studied indicated that the number of serotonin axons was increased in both pathways and terminal regions in cortex from autism donors. Our findings provide morphological evidence to warrant caution when using serotonin enhancing drugs (e.g. SSRIs and receptor agonist) to treat autistic children. This article is part of a Special Issue entitled 'Trends in Neuropharmacology: In Memory of Erminio Costa'.

Original languageEnglish (US)
Pages (from-to)1347-1354
Number of pages8
JournalNeuropharmacology
Volume60
Issue number7-8
DOIs
StatePublished - Jun 2011

Fingerprint

Autistic Disorder
Axons
Serotonin
Tissue Donors
Brain
Serotonin Plasma Membrane Transport Proteins
Serotonin Uptake Inhibitors
Neuropharmacology
Medial Forebrain Bundle
Serotonin Agents
Globus Pallidus
Temporal Lobe
Prosencephalon
Amygdala
Tryptophan
Antibodies
Pharmaceutical Preparations
Therapeutics

Keywords

  • Ansa lenticularis
  • Cerebral cortex
  • Medial forebrain bundle
  • Morphometrics
  • Stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors. / Azmitia, Efrain C.; Singh, Jorawer S.; Whitaker-Azmitia, Patricia M.

In: Neuropharmacology, Vol. 60, No. 7-8, 06.2011, p. 1347-1354.

Research output: Contribution to journalArticle

Azmitia, Efrain C. ; Singh, Jorawer S. ; Whitaker-Azmitia, Patricia M. / Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors. In: Neuropharmacology. 2011 ; Vol. 60, No. 7-8. pp. 1347-1354.
@article{ae039931388346359ff04739e4cc7c58,
title = "Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors",
abstract = "Imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. However, treatment with drugs which increase serotonin (5-HT) levels, specific serotonin reuptake inhibitors (SSRIs), commonly produce a worsening of the symptoms. In this study we examined 5-HT axons that were immunoreactive to a serotonin transporter (5-HTT) antibody in a number of postmortem brains from autistic patients and controls with no known diagnosis who ranged in age from 2 to 29 years. Fine, highly branched, and thick straight fibers were found in forebrain pathways (e.g. medial forebrain bundle, stria terminalis and ansa lenticularis). Many immunoreactive varicose fine fibers were seen in target areas (e.g. globus pallidus, amygdala and temporal cortex). Morphometric analysis of the stained axons at all ages studied indicated that the number of serotonin axons was increased in both pathways and terminal regions in cortex from autism donors. Our findings provide morphological evidence to warrant caution when using serotonin enhancing drugs (e.g. SSRIs and receptor agonist) to treat autistic children. This article is part of a Special Issue entitled 'Trends in Neuropharmacology: In Memory of Erminio Costa'.",
keywords = "Ansa lenticularis, Cerebral cortex, Medial forebrain bundle, Morphometrics, Stress",
author = "Azmitia, {Efrain C.} and Singh, {Jorawer S.} and Whitaker-Azmitia, {Patricia M.}",
year = "2011",
month = "6",
doi = "10.1016/j.neuropharm.2011.02.002",
language = "English (US)",
volume = "60",
pages = "1347--1354",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier Limited",
number = "7-8",

}

TY - JOUR

T1 - Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors

AU - Azmitia, Efrain C.

AU - Singh, Jorawer S.

AU - Whitaker-Azmitia, Patricia M.

PY - 2011/6

Y1 - 2011/6

N2 - Imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. However, treatment with drugs which increase serotonin (5-HT) levels, specific serotonin reuptake inhibitors (SSRIs), commonly produce a worsening of the symptoms. In this study we examined 5-HT axons that were immunoreactive to a serotonin transporter (5-HTT) antibody in a number of postmortem brains from autistic patients and controls with no known diagnosis who ranged in age from 2 to 29 years. Fine, highly branched, and thick straight fibers were found in forebrain pathways (e.g. medial forebrain bundle, stria terminalis and ansa lenticularis). Many immunoreactive varicose fine fibers were seen in target areas (e.g. globus pallidus, amygdala and temporal cortex). Morphometric analysis of the stained axons at all ages studied indicated that the number of serotonin axons was increased in both pathways and terminal regions in cortex from autism donors. Our findings provide morphological evidence to warrant caution when using serotonin enhancing drugs (e.g. SSRIs and receptor agonist) to treat autistic children. This article is part of a Special Issue entitled 'Trends in Neuropharmacology: In Memory of Erminio Costa'.

AB - Imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. However, treatment with drugs which increase serotonin (5-HT) levels, specific serotonin reuptake inhibitors (SSRIs), commonly produce a worsening of the symptoms. In this study we examined 5-HT axons that were immunoreactive to a serotonin transporter (5-HTT) antibody in a number of postmortem brains from autistic patients and controls with no known diagnosis who ranged in age from 2 to 29 years. Fine, highly branched, and thick straight fibers were found in forebrain pathways (e.g. medial forebrain bundle, stria terminalis and ansa lenticularis). Many immunoreactive varicose fine fibers were seen in target areas (e.g. globus pallidus, amygdala and temporal cortex). Morphometric analysis of the stained axons at all ages studied indicated that the number of serotonin axons was increased in both pathways and terminal regions in cortex from autism donors. Our findings provide morphological evidence to warrant caution when using serotonin enhancing drugs (e.g. SSRIs and receptor agonist) to treat autistic children. This article is part of a Special Issue entitled 'Trends in Neuropharmacology: In Memory of Erminio Costa'.

KW - Ansa lenticularis

KW - Cerebral cortex

KW - Medial forebrain bundle

KW - Morphometrics

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=79954592330&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954592330&partnerID=8YFLogxK

U2 - 10.1016/j.neuropharm.2011.02.002

DO - 10.1016/j.neuropharm.2011.02.002

M3 - Article

C2 - 21329710

AN - SCOPUS:79954592330

VL - 60

SP - 1347

EP - 1354

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 7-8

ER -