Increased paternal age and child health and development

Samantha Brenner, Karine Kleinhaus, Meredith Kursmark, Michael Weitzman

Research output: Contribution to journalReview article

Abstract

The large number of adverse health outcomes associated with advanced paternal age is not widely recognized by the pediatric community. An exploration of the clinical and public health implications of this issue is required so as to develop appropriate policies. Included in this review are the clinically relevant conditions and diseases currently known to be associated with increasing paternal age, including diminutions in child IQ and social function [1], increased rates of low birth weight, certain childhood cancers, autistic spectrum disorders, schizophrenia, achondroplasia, Apert syndrome, Crouzon syndrome, and Multiple Endocrine Neoplasia (MEN). Other conditions for which there may be increased rates, but for which the data are still inconclusive, also are discussed. As men delay childbearing in the developed world, there is a need for pediatricians to be aware of the potential consequences. This paper provides pediatricians with a reference for conditions in children that are related to advanced paternal age, assisting them in maintaining a high index of suspicion, and for use in responding to questions from parents about this issue.

Original languageEnglish (US)
Pages (from-to)135-146
Number of pages12
JournalCurrent Pediatric Reviews
Volume5
Issue number3
DOIs
StatePublished - Aug 1 2009

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Paternal Age
Child Development
Craniofacial Dysostosis
Acrocephalosyndactylia
Achondroplasia
Multiple Endocrine Neoplasia
Low Birth Weight Infant
Autistic Disorder
Schizophrenia
Public Health
Parents
Pediatrics
Health
Child Health
Neoplasms
Pediatricians

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Increased paternal age and child health and development. / Brenner, Samantha; Kleinhaus, Karine; Kursmark, Meredith; Weitzman, Michael.

In: Current Pediatric Reviews, Vol. 5, No. 3, 01.08.2009, p. 135-146.

Research output: Contribution to journalReview article

Brenner, Samantha ; Kleinhaus, Karine ; Kursmark, Meredith ; Weitzman, Michael. / Increased paternal age and child health and development. In: Current Pediatric Reviews. 2009 ; Vol. 5, No. 3. pp. 135-146.
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