Increased paternal age and child health and development

Samantha Brenner, Karine Kleinhaus, Meredith Kursmark, Michael Weitzman

    Research output: Contribution to journalReview article

    Abstract

    The large number of adverse health outcomes associated with advanced paternal age is not widely recognized by the pediatric community. An exploration of the clinical and public health implications of this issue is required so as to develop appropriate policies. Included in this review are the clinically relevant conditions and diseases currently known to be associated with increasing paternal age, including diminutions in child IQ and social function [1], increased rates of low birth weight, certain childhood cancers, autistic spectrum disorders, schizophrenia, achondroplasia, Apert syndrome, Crouzon syndrome, and Multiple Endocrine Neoplasia (MEN). Other conditions for which there may be increased rates, but for which the data are still inconclusive, also are discussed. As men delay childbearing in the developed world, there is a need for pediatricians to be aware of the potential consequences. This paper provides pediatricians with a reference for conditions in children that are related to advanced paternal age, assisting them in maintaining a high index of suspicion, and for use in responding to questions from parents about this issue.

    Original languageEnglish (US)
    Pages (from-to)135-146
    Number of pages12
    JournalCurrent Pediatric Reviews
    Volume5
    Issue number3
    DOIs
    StatePublished - Aug 1 2009

    Fingerprint

    Paternal Age
    Child Development
    Craniofacial Dysostosis
    Acrocephalosyndactylia
    Achondroplasia
    Multiple Endocrine Neoplasia
    Low Birth Weight Infant
    Autistic Disorder
    Schizophrenia
    Public Health
    Parents
    Pediatrics
    Health
    Child Health
    Neoplasms
    Pediatricians

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health

    Cite this

    Brenner, S., Kleinhaus, K., Kursmark, M., & Weitzman, M. (2009). Increased paternal age and child health and development. Current Pediatric Reviews, 5(3), 135-146. https://doi.org/10.2174/157339609789007178

    Increased paternal age and child health and development. / Brenner, Samantha; Kleinhaus, Karine; Kursmark, Meredith; Weitzman, Michael.

    In: Current Pediatric Reviews, Vol. 5, No. 3, 01.08.2009, p. 135-146.

    Research output: Contribution to journalReview article

    Brenner, S, Kleinhaus, K, Kursmark, M & Weitzman, M 2009, 'Increased paternal age and child health and development', Current Pediatric Reviews, vol. 5, no. 3, pp. 135-146. https://doi.org/10.2174/157339609789007178
    Brenner, Samantha ; Kleinhaus, Karine ; Kursmark, Meredith ; Weitzman, Michael. / Increased paternal age and child health and development. In: Current Pediatric Reviews. 2009 ; Vol. 5, No. 3. pp. 135-146.
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