Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS

Kirsten Neudoerffer Kangelaris, Arun Prakash, Kathleen D. Liu, Bradley Aouizerat, Prescott G. Woodruff, David J. Erle, Angela Rogers, Eric J. Seeley, Jeffrey Chu, Tom Liu, Thomas Osterberg-Deiss, Hanjing Zhuo, Michael A. Matthay, Carolyn S. Calfee

Research output: Contribution to journalArticle

Abstract

The early sequence of events leading to the development of the acute respiratory distress syndrome (ARDS) in patients with sepsis remains inadequately understood. The purpose of this study was to identify changes in gene expression early in the course of illness, when mechanisms of injury may provide the most relevant treatment and prognostic targets. We collected whole blood RNA in critically ill patients admitted from the Emergency Department to the intensive care unit within 24 h of admission at a tertiary care center. Whole genome expression was compared in patients with sepsis and ARDS to patients with sepsis alone. We selected genes with >1 log2 fold change and false discovery rate

Original languageEnglish (US)
Pages (from-to)L1102-L1113
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume308
Issue number11
DOIs
StatePublished - Jun 1 2015

Fingerprint

Adult Respiratory Distress Syndrome
Sepsis
Neutrophils
Genes
Tertiary Care Centers
Critical Illness
Intensive Care Units
Hospital Emergency Service
Genome
RNA
Gene Expression
Wounds and Injuries
Therapeutics

Keywords

  • ARDS
  • Gene expression
  • Neutrophils
  • Sepsis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology
  • Physiology

Cite this

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. / Kangelaris, Kirsten Neudoerffer; Prakash, Arun; Liu, Kathleen D.; Aouizerat, Bradley; Woodruff, Prescott G.; Erle, David J.; Rogers, Angela; Seeley, Eric J.; Chu, Jeffrey; Liu, Tom; Osterberg-Deiss, Thomas; Zhuo, Hanjing; Matthay, Michael A.; Calfee, Carolyn S.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 308, No. 11, 01.06.2015, p. L1102-L1113.

Research output: Contribution to journalArticle

Kangelaris, KN, Prakash, A, Liu, KD, Aouizerat, B, Woodruff, PG, Erle, DJ, Rogers, A, Seeley, EJ, Chu, J, Liu, T, Osterberg-Deiss, T, Zhuo, H, Matthay, MA & Calfee, CS 2015, 'Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 308, no. 11, pp. L1102-L1113. https://doi.org/10.1152/ajplung.00380.2014
Kangelaris, Kirsten Neudoerffer ; Prakash, Arun ; Liu, Kathleen D. ; Aouizerat, Bradley ; Woodruff, Prescott G. ; Erle, David J. ; Rogers, Angela ; Seeley, Eric J. ; Chu, Jeffrey ; Liu, Tom ; Osterberg-Deiss, Thomas ; Zhuo, Hanjing ; Matthay, Michael A. ; Calfee, Carolyn S. / Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 2015 ; Vol. 308, No. 11. pp. L1102-L1113.
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