Increased coronary collateral blood flow. A possible mechanism of action for betahistine-HCl

Louis Terracio, W. G. Kubicek

Research output: Contribution to journalArticle

Abstract

β-Histine-HCl has been shown to be effective in modifying the size of developing myocardial infarcts. In the present study the hypothesis that β-histine increases the flow of blood through collateral channels and thus supplies blood to ligated areas of the myocardium was investigated in the dog. The methods used were measurement of retrograde coronary blood flow and angiography after coronary artery ligation. β-Histine administration for 6 hr increased retrograde blood flow 68.2-91.0% over controls. Coronary angiography demonstrated the existence of collateral channels 200-400 μm in diameter within the myocardium after ligation and 4 hr of β-histine administration.

Original languageEnglish (US)
Pages (from-to)461-467
Number of pages7
JournalActa Anatomica
Volume103
Issue number4
StatePublished - 1979

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Betahistine
Ligation
Myocardium
Coronary Angiography
Coronary Vessels
Angiography
Myocardial Infarction
Dogs

ASJC Scopus subject areas

  • Anatomy

Cite this

Increased coronary collateral blood flow. A possible mechanism of action for betahistine-HCl. / Terracio, Louis; Kubicek, W. G.

In: Acta Anatomica, Vol. 103, No. 4, 1979, p. 461-467.

Research output: Contribution to journalArticle

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