Increased coronary collateral blood flow. A possible mechanism of action for betahistine-HCl

L. Terracio, W. G. Kubicek

Research output: Contribution to journalArticle


β-Histine-HCl has been shown to be effective in modifying the size of developing myocardial infarcts. In the present study the hypothesis that β-histine increases the flow of blood through collateral channels and thus supplies blood to ligated areas of the myocardium was investigated in the dog. The methods used were measurement of retrograde coronary blood flow and angiography after coronary artery ligation. β-Histine administration for 6 hr increased retrograde blood flow 68.2-91.0% over controls. Coronary angiography demonstrated the existence of collateral channels 200-400 μm in diameter within the myocardium after ligation and 4 hr of β-histine administration.

Original languageEnglish (US)
Pages (from-to)461-467
Number of pages7
JournalActa Anatomica
Issue number4
StatePublished - Dec 1 1979


ASJC Scopus subject areas

  • Anatomy

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