Incidence of prostate and urological cancers in England by ethnic group, 2001-2007: A descriptive study

Mahiben Maruthappu, Isobel Barnes, Shameq Sayeed, Raghib Ali

Research output: Contribution to journalArticle

Abstract

Background: The aetiology of urological cancers is poorly understood and variations in incidence by ethnic group may provide insights into the relative importance of genetic and environmental risk factors. Our objective was to compare the incidence of four urological cancers (kidney, bladder, prostate and testicular) among six 'non-White' ethnic groups in England (Indian, Pakistani, Bangladeshi, Black African, Black Caribbean and Chinese) to each other and to Whites. Methods: We obtained Information on ethnicity for all urological cancer registrations from 2001 to 2007 (n = 329,524) by linkage to the Hospital Episodes Statistics database. We calculated incidence rate ratios adjusted for age, sex and income, comparing the six ethnic groups (and combined 'South Asian' and 'Black' groups) to Whites and to each other. Results: There were significant differences in the incidence of all four cancers between the ethnic groups (all p < 0.001). In general, 'non-White' groups had a lower incidence of urological cancers compared to Whites, except prostate cancer, which displayed a higher incidence in Blacks. (IRR 2.55) There was strong evidence of differences in risk between Indians, Pakistanis and Bangladeshis for kidney, bladder and prostate cancer (p < 0.001), and between Black Africans and Black Caribbeans for all four cancers (p < 0.001). Conclusions: The risk of urological cancers in England varies greatly by ethnicity, including within groups that have traditionally been analysed together (South Asians and Blacks). In general, these differences are not readily explained by known risk factors, although the very high incidence of prostate cancer in both black Africans and Caribbeans suggests increased genetic susceptibility. g.

Original languageEnglish (US)
Article number753
JournalBMC Cancer
Volume15
Issue number1
DOIs
StatePublished - Oct 21 2015

Fingerprint

Urologic Neoplasms
Ethnic Groups
England
Prostatic Neoplasms
Incidence
Kidney Neoplasms
Urinary Bladder Neoplasms
Genetic Predisposition to Disease
Prostate
Neoplasms
Databases

Keywords

  • Bladder
  • Cancer
  • Ethnic
  • Incidence
  • Kidney
  • Prostate
  • Testicular
  • Urological

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Incidence of prostate and urological cancers in England by ethnic group, 2001-2007 : A descriptive study. / Maruthappu, Mahiben; Barnes, Isobel; Sayeed, Shameq; Ali, Raghib.

In: BMC Cancer, Vol. 15, No. 1, 753, 21.10.2015.

Research output: Contribution to journalArticle

Maruthappu, Mahiben ; Barnes, Isobel ; Sayeed, Shameq ; Ali, Raghib. / Incidence of prostate and urological cancers in England by ethnic group, 2001-2007 : A descriptive study. In: BMC Cancer. 2015 ; Vol. 15, No. 1.
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KW - Bladder

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