Inappropriate Left Ventricular Mass and Cardiovascular Disease Events and Mortality in Blacks: The Jackson Heart Study

D. Edmund Anstey, Rikki M. Tanner, John N. Booth, Adam P. Bress, Keith M. Diaz, Mario Sims, Olugbenga Ogedegbe, Paul Muntner, Marwah Abdalla

Research output: Contribution to journalArticle

Abstract

Background Left ventricular hypertrophy (LVH) is associated with an increased risk for cardiovascular disease (CVD) events and all-cause mortality. Many individuals without LVH have a left ventricular mass that exceeds the level predicted by their sex, body size, and cardiac workload, a condition called inappropriate left ventricular mass (iLVM). We investigated the association of iLVM with CVD events and all-cause mortality among blacks. Methods and Results We analyzed data from the Jackson Heart Study, a community-based cohort of blacks. The current analysis included 4424 participants without CVD and with an echocardiogram at baseline. Among this cohort, the prevalence of iLVM was 13.8%. There were 262 CVD events and 419 deaths over a median follow-up of 9.7 years (maximum, 12 years). Compared with participants without iLVM, participants with iLVM had a higher rate of CVD events and all-cause mortality. After multivariable adjustment, including for the presence of LVH, iLVM was associated with an increased risk of CVD events (hazard ratio, 1.87; 95% CI, 1.33-2.62). The multivariable-adjusted hazard ratio for all-cause mortality was 1.29 (95% CI, 0.98-1.70). Among participants without and with LVH, the multivariable-adjusted hazard ratios of iLVM for CVD events were 2.53 (95% CI, 1.68-3.81) and 1.21 (95% CI, 0.74-2.00), respectively (Pinteraction=0.029); and for all-cause mortality, the hazard ratios were 1.24 (95% CI, 0.81-1.89) and 1.26 (95% CI, 0.86-1.85), respectively (Pinteraction=0.664). Conclusions iLVM is associated with an increased risk for CVD events among blacks without LVH.

Original languageEnglish (US)
Pages (from-to)e011897
JournalJournal of the American Heart Association
Volume8
Issue number16
DOIs
StatePublished - Aug 20 2019

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Cardiovascular Diseases
Left Ventricular Hypertrophy
Mortality
Body Size
Workload

Keywords

  • black
  • cardiovascular disease
  • inappropriate left ventricular mass
  • left ventricular hypertrophy
  • mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Inappropriate Left Ventricular Mass and Cardiovascular Disease Events and Mortality in Blacks : The Jackson Heart Study. / Anstey, D. Edmund; Tanner, Rikki M.; Booth, John N.; Bress, Adam P.; Diaz, Keith M.; Sims, Mario; Ogedegbe, Olugbenga; Muntner, Paul; Abdalla, Marwah.

In: Journal of the American Heart Association, Vol. 8, No. 16, 20.08.2019, p. e011897.

Research output: Contribution to journalArticle

Anstey, D. Edmund ; Tanner, Rikki M. ; Booth, John N. ; Bress, Adam P. ; Diaz, Keith M. ; Sims, Mario ; Ogedegbe, Olugbenga ; Muntner, Paul ; Abdalla, Marwah. / Inappropriate Left Ventricular Mass and Cardiovascular Disease Events and Mortality in Blacks : The Jackson Heart Study. In: Journal of the American Heart Association. 2019 ; Vol. 8, No. 16. pp. e011897.
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abstract = "Background Left ventricular hypertrophy (LVH) is associated with an increased risk for cardiovascular disease (CVD) events and all-cause mortality. Many individuals without LVH have a left ventricular mass that exceeds the level predicted by their sex, body size, and cardiac workload, a condition called inappropriate left ventricular mass (iLVM). We investigated the association of iLVM with CVD events and all-cause mortality among blacks. Methods and Results We analyzed data from the Jackson Heart Study, a community-based cohort of blacks. The current analysis included 4424 participants without CVD and with an echocardiogram at baseline. Among this cohort, the prevalence of iLVM was 13.8{\%}. There were 262 CVD events and 419 deaths over a median follow-up of 9.7 years (maximum, 12 years). Compared with participants without iLVM, participants with iLVM had a higher rate of CVD events and all-cause mortality. After multivariable adjustment, including for the presence of LVH, iLVM was associated with an increased risk of CVD events (hazard ratio, 1.87; 95{\%} CI, 1.33-2.62). The multivariable-adjusted hazard ratio for all-cause mortality was 1.29 (95{\%} CI, 0.98-1.70). Among participants without and with LVH, the multivariable-adjusted hazard ratios of iLVM for CVD events were 2.53 (95{\%} CI, 1.68-3.81) and 1.21 (95{\%} CI, 0.74-2.00), respectively (Pinteraction=0.029); and for all-cause mortality, the hazard ratios were 1.24 (95{\%} CI, 0.81-1.89) and 1.26 (95{\%} CI, 0.86-1.85), respectively (Pinteraction=0.664). Conclusions iLVM is associated with an increased risk for CVD events among blacks without LVH.",
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T1 - Inappropriate Left Ventricular Mass and Cardiovascular Disease Events and Mortality in Blacks

T2 - The Jackson Heart Study

AU - Anstey, D. Edmund

AU - Tanner, Rikki M.

AU - Booth, John N.

AU - Bress, Adam P.

AU - Diaz, Keith M.

AU - Sims, Mario

AU - Ogedegbe, Olugbenga

AU - Muntner, Paul

AU - Abdalla, Marwah

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N2 - Background Left ventricular hypertrophy (LVH) is associated with an increased risk for cardiovascular disease (CVD) events and all-cause mortality. Many individuals without LVH have a left ventricular mass that exceeds the level predicted by their sex, body size, and cardiac workload, a condition called inappropriate left ventricular mass (iLVM). We investigated the association of iLVM with CVD events and all-cause mortality among blacks. Methods and Results We analyzed data from the Jackson Heart Study, a community-based cohort of blacks. The current analysis included 4424 participants without CVD and with an echocardiogram at baseline. Among this cohort, the prevalence of iLVM was 13.8%. There were 262 CVD events and 419 deaths over a median follow-up of 9.7 years (maximum, 12 years). Compared with participants without iLVM, participants with iLVM had a higher rate of CVD events and all-cause mortality. After multivariable adjustment, including for the presence of LVH, iLVM was associated with an increased risk of CVD events (hazard ratio, 1.87; 95% CI, 1.33-2.62). The multivariable-adjusted hazard ratio for all-cause mortality was 1.29 (95% CI, 0.98-1.70). Among participants without and with LVH, the multivariable-adjusted hazard ratios of iLVM for CVD events were 2.53 (95% CI, 1.68-3.81) and 1.21 (95% CI, 0.74-2.00), respectively (Pinteraction=0.029); and for all-cause mortality, the hazard ratios were 1.24 (95% CI, 0.81-1.89) and 1.26 (95% CI, 0.86-1.85), respectively (Pinteraction=0.664). Conclusions iLVM is associated with an increased risk for CVD events among blacks without LVH.

AB - Background Left ventricular hypertrophy (LVH) is associated with an increased risk for cardiovascular disease (CVD) events and all-cause mortality. Many individuals without LVH have a left ventricular mass that exceeds the level predicted by their sex, body size, and cardiac workload, a condition called inappropriate left ventricular mass (iLVM). We investigated the association of iLVM with CVD events and all-cause mortality among blacks. Methods and Results We analyzed data from the Jackson Heart Study, a community-based cohort of blacks. The current analysis included 4424 participants without CVD and with an echocardiogram at baseline. Among this cohort, the prevalence of iLVM was 13.8%. There were 262 CVD events and 419 deaths over a median follow-up of 9.7 years (maximum, 12 years). Compared with participants without iLVM, participants with iLVM had a higher rate of CVD events and all-cause mortality. After multivariable adjustment, including for the presence of LVH, iLVM was associated with an increased risk of CVD events (hazard ratio, 1.87; 95% CI, 1.33-2.62). The multivariable-adjusted hazard ratio for all-cause mortality was 1.29 (95% CI, 0.98-1.70). Among participants without and with LVH, the multivariable-adjusted hazard ratios of iLVM for CVD events were 2.53 (95% CI, 1.68-3.81) and 1.21 (95% CI, 0.74-2.00), respectively (Pinteraction=0.029); and for all-cause mortality, the hazard ratios were 1.24 (95% CI, 0.81-1.89) and 1.26 (95% CI, 0.86-1.85), respectively (Pinteraction=0.664). Conclusions iLVM is associated with an increased risk for CVD events among blacks without LVH.

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KW - mortality

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