Abstract
Synthetic photoswitches have been known for many years, but their usefulness in biology, pharmacology, and medicine has only recently been systematically explored. Over the past decade photopharmacology has grown into a vibrant field. As the photophysical, pharmacodynamic, and pharmacokinetic properties of photoswitches, such as azobenzenes, have become established, they have been applied to a wide range of biological targets. These include transmembrane proteins (ion channels, transporters, G protein-coupled receptors, receptor-linked enzymes), soluble proteins (kinases, proteases, factors involved in epigenetic regulation), lipid membranes, and nucleic acids. In this review, we provide an overview of photopharmacology using synthetic switches that have been applied in vivo, i.e., in living cells and organisms. We discuss the scope and limitations of this approach to study biological function and the challenges it faces in translational medicine. The relationships between synthetic photoswitches, natural chromophores used in optogenetics, and caged ligands are addressed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10710-10747 |
| Number of pages | 38 |
| Journal | Chemical Reviews |
| Volume | 118 |
| Issue number | 21 |
| DOIs | |
| State | Published - Nov 14 2018 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
In Vivo Photopharmacology. / Hüll, Katharina; Morstein, Johannes; Trauner, Dirk.
In: Chemical Reviews, Vol. 118, No. 21, 14.11.2018, p. 10710-10747.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - In Vivo Photopharmacology
AU - Hüll, Katharina
AU - Morstein, Johannes
AU - Trauner, Dirk
PY - 2018/11/14
Y1 - 2018/11/14
N2 - Synthetic photoswitches have been known for many years, but their usefulness in biology, pharmacology, and medicine has only recently been systematically explored. Over the past decade photopharmacology has grown into a vibrant field. As the photophysical, pharmacodynamic, and pharmacokinetic properties of photoswitches, such as azobenzenes, have become established, they have been applied to a wide range of biological targets. These include transmembrane proteins (ion channels, transporters, G protein-coupled receptors, receptor-linked enzymes), soluble proteins (kinases, proteases, factors involved in epigenetic regulation), lipid membranes, and nucleic acids. In this review, we provide an overview of photopharmacology using synthetic switches that have been applied in vivo, i.e., in living cells and organisms. We discuss the scope and limitations of this approach to study biological function and the challenges it faces in translational medicine. The relationships between synthetic photoswitches, natural chromophores used in optogenetics, and caged ligands are addressed.
AB - Synthetic photoswitches have been known for many years, but their usefulness in biology, pharmacology, and medicine has only recently been systematically explored. Over the past decade photopharmacology has grown into a vibrant field. As the photophysical, pharmacodynamic, and pharmacokinetic properties of photoswitches, such as azobenzenes, have become established, they have been applied to a wide range of biological targets. These include transmembrane proteins (ion channels, transporters, G protein-coupled receptors, receptor-linked enzymes), soluble proteins (kinases, proteases, factors involved in epigenetic regulation), lipid membranes, and nucleic acids. In this review, we provide an overview of photopharmacology using synthetic switches that have been applied in vivo, i.e., in living cells and organisms. We discuss the scope and limitations of this approach to study biological function and the challenges it faces in translational medicine. The relationships between synthetic photoswitches, natural chromophores used in optogenetics, and caged ligands are addressed.
UR - http://www.scopus.com/inward/record.url?scp=85056214189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056214189&partnerID=8YFLogxK
U2 - 10.1021/acs.chemrev.8b00037
DO - 10.1021/acs.chemrev.8b00037
M3 - Review article
VL - 118
SP - 10710
EP - 10747
JO - Chemical Reviews
JF - Chemical Reviews
SN - 0009-2665
IS - 21
ER -