In vivo distribution of a vaginal gel: MRI evaluation of the effects of gel volume, time and simulated intercourse

Kurt Thomas Barnhart, E. Scott Pretorius, Kelly Timbers, David Shera, Mayadah Shabbout, Daniel Malamud

Research output: Contribution to journalArticle


A microbicide is designed to coat the vaginal epithelium and prevent transmission of HIV. Complete coverage is desired for optimal protection. In vivo factors affecting coverage have not yet been studied. This randomized crossover trial evaluates the effect of gel volume and patient activity upon vaginal epithelial coating. Gynol II gel was mixed with a magnetic resonance imaging (MRI) contrast agent. Ten women self-inserted, on separate visits, 3 or 5 mL of gel and underwent serial MRI scanning both before and after simulated intercourse. Gel spread was dependent upon time and volume. There was modest spread during the first hour and greater spread 6 h after insertion. Five milliliters of gel resulted in statistically significantly greater coverage immediately following insertion, within the first 30 min and at 6 h after insertion. Simulated intercourse greatly enhances gel spread. After simulated intercourse, the distribution of the gel at each volume was similar. Less leakage of gel was reported with the smaller volume.

Original languageEnglish (US)
Pages (from-to)498-505
Number of pages8
Issue number6
StatePublished - Dec 1 2004



  • HIV
  • MRI
  • Microbicide
  • Spermicide
  • Vagina

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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