In vivo and in vitro evaluation of the influence of aromatic retinoid RO 10-9359 and of its metabolite TMMP-RA, RO 10-1670 on polymorphonuclear leukocyte and lymphocyte functions in psoriatic subjects

M. Marconi, D. Montagna, C. Alberini

Research output: Contribution to journalArticle

Abstract

Lymphocytes and polymorphonuclear leukocytes functions of 10 psoriatic patients treated with aromatic retinoid RO 10-9359 were investigated. No changes of OK-T subpopulations were observed before, during (days 7, 14) and at the end of treatment (day 21). No alterations of PMNs functions investigated (chemotaxis, bactericidal activity, phagocytosis, NBT test reduction, respiratory burst) before, during and after treatment were observed. Lymphocyte responsiveness to polyclonal mitogens (PHA, ConA, PWM) were basically normal and decreased during treatment. No influences of the metabolite RO 10-1670 on PMNs chemotaxis in vitro could be shown.

Original languageEnglish (US)
Pages (from-to)47-49
Number of pages3
JournalActa Dermato-Venereologica
Volume64
Issue numberSUPPL. 113
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Dermatology

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