Improved assessment of cartilage repair tissue using fluid-suppressed 23Na inversion recovery MRI at 7 Tesla: Preliminary results

Gregory Chang, Guillaume Madelin, Orrin H. Sherman, Eric J. Strauss, Ding Xia, Michael P. Recht, Alexej Jerschow, Ravinder R. Regatte

Research output: Contribution to journalArticle

Abstract

Objectives To evaluate cartilage repair and native tissue using a three-dimensional (3D), radial, ultra-short echo time (UTE) 23Na MR sequence without and with an inversion recovery (IR) preparation pulse for fluid suppression at 7 Tesla (T). Methods This study had institutional review board approval. We recruited 11 consecutive patients (41.5±11.8 years) from an orthopaedic surgery practice who had undergone a knee cartilage restoration procedure. The subjects were examined postoperatively (median=26 weeks) with 7-T MRI using: proton-T2 (TR/TE=3,000 ms/60 ms); sodium UTE (TR/TE=100 ms/0.4 ms); fluid-suppressed, sodium UTE adiabatic IR. Cartilage sodium concentrations in repair tissue ([Na +] R), adjacent native cartilage ([Na +] N), and native cartilage within the opposite, non-surgical compartment ([Na +] N2) were calculated using external NaCl phantoms. Results For conventional sodium imaging, mean [Na +] R, [Na +] N, [Na +] N2 were 177.8±54.1 mM, 170.1±40.7 mM, 172.2±30 mM respectively. Differences in [Na +] R versus [Na +] N (P=0.59) and [Na +] N versus [Na +] N2 (P=0.89) were not significant. For sodium IR imaging, mean [Na +] R, [Na +] N, [Na +] N2 were 108.9±29.8 mM, 204.6±34.7 mM, 249.9± 44.6 mM respectively. Decreases in [Na +] R versus [Na +] N (P=0.0.0000035) and [Na +] N versus [Na +] N2 (P=0.015) were significant. Conclusions Sodium IR imaging at 7 T can suppress the signal from free sodium within synovial fluid. This may allow improved assessment of [Na +] within cartilage repair and native tissue. Key Points • NaIR magnetic resonance imaging can suppress signal from sodium within synovial fluid. • NaIR MRI thus allows assessment of sodium concentration within cartilage tissue alone. • This may facilitate more accurate assessment of repair tissue composition and quality.

Original languageEnglish (US)
Pages (from-to)1341-1349
Number of pages9
JournalEuropean Radiology
Volume22
Issue number6
DOIs
StatePublished - Jun 2012

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Cartilage
Sodium
Synovial Fluid
Research Ethics Committees
Orthopedics
Protons
Knee
Magnetic Resonance Imaging

Keywords

  • 7 Tesla
  • Cartilage repair
  • Inversion recovery
  • Sodium MRI
  • Ultra-high field

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Chang, G., Madelin, G., Sherman, O. H., Strauss, E. J., Xia, D., Recht, M. P., ... Regatte, R. R. (2012). Improved assessment of cartilage repair tissue using fluid-suppressed 23Na inversion recovery MRI at 7 Tesla: Preliminary results. European Radiology, 22(6), 1341-1349. https://doi.org/10.1007/s00330-012-2383-8

Improved assessment of cartilage repair tissue using fluid-suppressed 23Na inversion recovery MRI at 7 Tesla : Preliminary results. / Chang, Gregory; Madelin, Guillaume; Sherman, Orrin H.; Strauss, Eric J.; Xia, Ding; Recht, Michael P.; Jerschow, Alexej; Regatte, Ravinder R.

In: European Radiology, Vol. 22, No. 6, 06.2012, p. 1341-1349.

Research output: Contribution to journalArticle

Chang, Gregory ; Madelin, Guillaume ; Sherman, Orrin H. ; Strauss, Eric J. ; Xia, Ding ; Recht, Michael P. ; Jerschow, Alexej ; Regatte, Ravinder R. / Improved assessment of cartilage repair tissue using fluid-suppressed 23Na inversion recovery MRI at 7 Tesla : Preliminary results. In: European Radiology. 2012 ; Vol. 22, No. 6. pp. 1341-1349.
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AU - Strauss, Eric J.

AU - Xia, Ding

AU - Recht, Michael P.

AU - Jerschow, Alexej

AU - Regatte, Ravinder R.

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N2 - Objectives To evaluate cartilage repair and native tissue using a three-dimensional (3D), radial, ultra-short echo time (UTE) 23Na MR sequence without and with an inversion recovery (IR) preparation pulse for fluid suppression at 7 Tesla (T). Methods This study had institutional review board approval. We recruited 11 consecutive patients (41.5±11.8 years) from an orthopaedic surgery practice who had undergone a knee cartilage restoration procedure. The subjects were examined postoperatively (median=26 weeks) with 7-T MRI using: proton-T2 (TR/TE=3,000 ms/60 ms); sodium UTE (TR/TE=100 ms/0.4 ms); fluid-suppressed, sodium UTE adiabatic IR. Cartilage sodium concentrations in repair tissue ([Na +] R), adjacent native cartilage ([Na +] N), and native cartilage within the opposite, non-surgical compartment ([Na +] N2) were calculated using external NaCl phantoms. Results For conventional sodium imaging, mean [Na +] R, [Na +] N, [Na +] N2 were 177.8±54.1 mM, 170.1±40.7 mM, 172.2±30 mM respectively. Differences in [Na +] R versus [Na +] N (P=0.59) and [Na +] N versus [Na +] N2 (P=0.89) were not significant. For sodium IR imaging, mean [Na +] R, [Na +] N, [Na +] N2 were 108.9±29.8 mM, 204.6±34.7 mM, 249.9± 44.6 mM respectively. Decreases in [Na +] R versus [Na +] N (P=0.0.0000035) and [Na +] N versus [Na +] N2 (P=0.015) were significant. Conclusions Sodium IR imaging at 7 T can suppress the signal from free sodium within synovial fluid. This may allow improved assessment of [Na +] within cartilage repair and native tissue. Key Points • NaIR magnetic resonance imaging can suppress signal from sodium within synovial fluid. • NaIR MRI thus allows assessment of sodium concentration within cartilage tissue alone. • This may facilitate more accurate assessment of repair tissue composition and quality.

AB - Objectives To evaluate cartilage repair and native tissue using a three-dimensional (3D), radial, ultra-short echo time (UTE) 23Na MR sequence without and with an inversion recovery (IR) preparation pulse for fluid suppression at 7 Tesla (T). Methods This study had institutional review board approval. We recruited 11 consecutive patients (41.5±11.8 years) from an orthopaedic surgery practice who had undergone a knee cartilage restoration procedure. The subjects were examined postoperatively (median=26 weeks) with 7-T MRI using: proton-T2 (TR/TE=3,000 ms/60 ms); sodium UTE (TR/TE=100 ms/0.4 ms); fluid-suppressed, sodium UTE adiabatic IR. Cartilage sodium concentrations in repair tissue ([Na +] R), adjacent native cartilage ([Na +] N), and native cartilage within the opposite, non-surgical compartment ([Na +] N2) were calculated using external NaCl phantoms. Results For conventional sodium imaging, mean [Na +] R, [Na +] N, [Na +] N2 were 177.8±54.1 mM, 170.1±40.7 mM, 172.2±30 mM respectively. Differences in [Na +] R versus [Na +] N (P=0.59) and [Na +] N versus [Na +] N2 (P=0.89) were not significant. For sodium IR imaging, mean [Na +] R, [Na +] N, [Na +] N2 were 108.9±29.8 mM, 204.6±34.7 mM, 249.9± 44.6 mM respectively. Decreases in [Na +] R versus [Na +] N (P=0.0.0000035) and [Na +] N versus [Na +] N2 (P=0.015) were significant. Conclusions Sodium IR imaging at 7 T can suppress the signal from free sodium within synovial fluid. This may allow improved assessment of [Na +] within cartilage repair and native tissue. Key Points • NaIR magnetic resonance imaging can suppress signal from sodium within synovial fluid. • NaIR MRI thus allows assessment of sodium concentration within cartilage tissue alone. • This may facilitate more accurate assessment of repair tissue composition and quality.

KW - 7 Tesla

KW - Cartilage repair

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