Imperfect gold standards for biomarker evaluation

Sushrut S. Waikar, Rebecca Betensky, Sarah C. Emerson, Joseph V. Bonventre

Research output: Contribution to journalArticle

Abstract

Background Serum creatinine has been used as the diagnostic test for acute kidney injury (AKI) for decades despite having imperfect sensitivity and specificity. Novel tubular injury biomarkers may revolutionize the diagnosis of KI; however, even if a novel tubular injury biomarker is 100% sensitive and 100% specific, it may appear inaccurate when using serum creatinine as the gold standard. Conclusions In general, the apparent diagnostic performance of a biomarker depends not only on its ability to detect injury but also on disease prevalence and the sensitivity and specificity of the imperfect gold standard. Apparent errors in diagnosis using a new biomarker may be a reflection of errors in the imperfect gold standard itself rather than poor performance of the biomarker. Clinical Trials 2013; 10: 696700. http://ctj.sagepub.com.

Original languageEnglish (US)
Pages (from-to)696-700
Number of pages5
JournalClinical Trials
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2013

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Biomarkers
Creatinine
Wounds and Injuries
Sensitivity and Specificity
Serum
Routine Diagnostic Tests
Acute Kidney Injury
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology

Cite this

Imperfect gold standards for biomarker evaluation. / Waikar, Sushrut S.; Betensky, Rebecca; Emerson, Sarah C.; Bonventre, Joseph V.

In: Clinical Trials, Vol. 10, No. 5, 01.10.2013, p. 696-700.

Research output: Contribution to journalArticle

Waikar, SS, Betensky, R, Emerson, SC & Bonventre, JV 2013, 'Imperfect gold standards for biomarker evaluation', Clinical Trials, vol. 10, no. 5, pp. 696-700. https://doi.org/10.1177/1740774513497540
Waikar, Sushrut S. ; Betensky, Rebecca ; Emerson, Sarah C. ; Bonventre, Joseph V. / Imperfect gold standards for biomarker evaluation. In: Clinical Trials. 2013 ; Vol. 10, No. 5. pp. 696-700.
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