Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase

E. Thiels, N. N. Urban, G. R. Gonzalez-Burgos, B. I. Kanterewicz, G. Barrionuevo, C. T. Chu, T. D. Oury, Eric Klann

Research output: Contribution to journalArticle

Abstract

Reactive oxygen species, including superoxide, generally are considered neurotoxic molecules whose effects can be alleviated by antioxidants. Different from this view, we show that scavenging of superoxide with an antioxidant enzyme is associated with deficits in hippocampal long-term potentiation (LTP), a putative neural substrate of memory, and hippocampal-mediated memory function. Using transgenic mice that overexpress extracellular superoxide dismutase (EC-SOD), a superoxide scavenger, we found that LTP was impaired in hippocampal area CA1 despite normal LTP in area CA3. The LTP impairment in area CA1 could be reversed by inhibition of EC-SOD. In addition, we found that EC-SOD transgenic mice exhibited impaired long-term memory of fear conditioning to contextual cues despite exhibiting normal short-term memory of the conditioning experience. These findings strongly suggest that superoxide, rather than being considered exclusively a neurotoxic molecule, should also be considered a signaling molecule necessary for normal neuronal function.

Original languageEnglish (US)
Pages (from-to)7631-7639
Number of pages9
JournalJournal of Neuroscience
Volume20
Issue number20
StatePublished - Oct 15 2000

Fingerprint

Long-Term Potentiation
Superoxides
Superoxide Dismutase
Transgenic Mice
Antioxidants
Long-Term Memory
Short-Term Memory
Fear
Cues
Reactive Oxygen Species
Enzymes
Conditioning (Psychology)

Keywords

  • Associative memory
  • Contextual fear conditioning
  • EC-SOD
  • Hydrogen peroxide
  • LTP
  • Superoxide

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Thiels, E., Urban, N. N., Gonzalez-Burgos, G. R., Kanterewicz, B. I., Barrionuevo, G., Chu, C. T., ... Klann, E. (2000). Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase. Journal of Neuroscience, 20(20), 7631-7639.

Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase. / Thiels, E.; Urban, N. N.; Gonzalez-Burgos, G. R.; Kanterewicz, B. I.; Barrionuevo, G.; Chu, C. T.; Oury, T. D.; Klann, Eric.

In: Journal of Neuroscience, Vol. 20, No. 20, 15.10.2000, p. 7631-7639.

Research output: Contribution to journalArticle

Thiels, E, Urban, NN, Gonzalez-Burgos, GR, Kanterewicz, BI, Barrionuevo, G, Chu, CT, Oury, TD & Klann, E 2000, 'Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase', Journal of Neuroscience, vol. 20, no. 20, pp. 7631-7639.
Thiels E, Urban NN, Gonzalez-Burgos GR, Kanterewicz BI, Barrionuevo G, Chu CT et al. Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase. Journal of Neuroscience. 2000 Oct 15;20(20):7631-7639.
Thiels, E. ; Urban, N. N. ; Gonzalez-Burgos, G. R. ; Kanterewicz, B. I. ; Barrionuevo, G. ; Chu, C. T. ; Oury, T. D. ; Klann, Eric. / Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase. In: Journal of Neuroscience. 2000 ; Vol. 20, No. 20. pp. 7631-7639.
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