Impairment of decision-making in multiple sclerosis: A neuroeconomic approach

Maria Sepúlveda, Begoña Fernández-Diez, Elena H. Martínez-Lapiscina, Sara Llufriu, Nuria Sola-Valls, Irati Zubizarreta, Yolanda Blanco, Albert Saiz, Dino Levy, Paul Glimcher, Pablo Villoslada

Research output: Contribution to journalArticle

Abstract

Objective: To assess the decision-making impairment in patients with multiple sclerosis (MS) and how they relate to other cognitive domains. Methods: We performed a cross-sectional analysis in 84 patients with MS, and 21 matched healthy controls using four tasks taken from behavioral economics: (1) risk preferences, (2) choice consistency, (3) delay of gratification, and (4) rate of learning. All tasks were conducted using real-world reward outcomes (food or money) in different real-life conditions. Participants underwent cognitive examination using the Brief Repeatable Battery-Neuropsychology. Results: Patients showed higher risk aversion (general propensity to choose the lottery was 0.51 vs 0.64, p = 0.009), a trend to choose more immediate rewards over larger but delayed rewards (p = 0.108), and had longer reactions times (p = 0.033). Choice consistency and learning rates were not different between groups. Progressive patients chose slower than relapsing patients. In relation to general cognitive impairments, we found correlations between impaired decision-making and impaired verbal memory (r = 0.29, p = 0.009), visual memory (r = −0.37, p = 0.001), and reduced processing speed (r = −0.32, p = 0.001). Normalized gray matter volume correlated with deliberation time (r = −0.32, p = 0.005). Conclusion: Patients with MS suffer significant decision-making impairments, even at the early stages of the disease, and may affect patients’ quality and social life.

Original languageEnglish (US)
Pages (from-to)1762-1771
Number of pages10
JournalMultiple Sclerosis
Volume23
Issue number13
DOIs
StatePublished - Nov 1 2017

Fingerprint

Multiple Sclerosis
Decision Making
Reward
Behavioral Economics
Learning
Neuropsychology
Reaction Time
Cross-Sectional Studies
Quality of Life
Food

Keywords

  • cognitive impairment
  • decision-making
  • Multiple sclerosis
  • neuroeconomics

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Sepúlveda, M., Fernández-Diez, B., Martínez-Lapiscina, E. H., Llufriu, S., Sola-Valls, N., Zubizarreta, I., ... Villoslada, P. (2017). Impairment of decision-making in multiple sclerosis: A neuroeconomic approach. Multiple Sclerosis, 23(13), 1762-1771. https://doi.org/10.1177/1352458516682103

Impairment of decision-making in multiple sclerosis : A neuroeconomic approach. / Sepúlveda, Maria; Fernández-Diez, Begoña; Martínez-Lapiscina, Elena H.; Llufriu, Sara; Sola-Valls, Nuria; Zubizarreta, Irati; Blanco, Yolanda; Saiz, Albert; Levy, Dino; Glimcher, Paul; Villoslada, Pablo.

In: Multiple Sclerosis, Vol. 23, No. 13, 01.11.2017, p. 1762-1771.

Research output: Contribution to journalArticle

Sepúlveda, M, Fernández-Diez, B, Martínez-Lapiscina, EH, Llufriu, S, Sola-Valls, N, Zubizarreta, I, Blanco, Y, Saiz, A, Levy, D, Glimcher, P & Villoslada, P 2017, 'Impairment of decision-making in multiple sclerosis: A neuroeconomic approach', Multiple Sclerosis, vol. 23, no. 13, pp. 1762-1771. https://doi.org/10.1177/1352458516682103
Sepúlveda M, Fernández-Diez B, Martínez-Lapiscina EH, Llufriu S, Sola-Valls N, Zubizarreta I et al. Impairment of decision-making in multiple sclerosis: A neuroeconomic approach. Multiple Sclerosis. 2017 Nov 1;23(13):1762-1771. https://doi.org/10.1177/1352458516682103
Sepúlveda, Maria ; Fernández-Diez, Begoña ; Martínez-Lapiscina, Elena H. ; Llufriu, Sara ; Sola-Valls, Nuria ; Zubizarreta, Irati ; Blanco, Yolanda ; Saiz, Albert ; Levy, Dino ; Glimcher, Paul ; Villoslada, Pablo. / Impairment of decision-making in multiple sclerosis : A neuroeconomic approach. In: Multiple Sclerosis. 2017 ; Vol. 23, No. 13. pp. 1762-1771.
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