IgG antibody levels to Porphyromonas gingivalis and clinical measures in children

Cara L. Donley, Rachel Badovinac, Shabtai Sapir, Lior Shapira, Yael Houri, Alpdogan Kantarci, Martha L. Warbington, Serge Dibart, Thomas E. Van Dyke, Howard L. Needleman, Nadeem Karimbux, Enrique Bimstein

Research output: Contribution to journalArticle

Abstract

Background: Periodontopathic clinical markers are poorly understood in the pediatric population. Several studies have proposed Porphyromonas gingivalis (P. gingivalis) and an antibody response to the microorganism as factors in periodontal tissue destruction in children. The objective of this study was to examine the prevalence of P. gingivalis in dental plaque and of serum immunoglobulin G (IgG) antibody levels to P. gingivalis, and their relationship to periodontal clinical measures in children. Methods: Thirty-one subjects, aged 20 to 163 months, participated in this study. Clinical measures examined included gingivitis, plaque, alveolar bone height, age, gender, ethnicity, medical status, caries, and IgG antibody levels to P. gingivalis. Five ml of blood was collected for serum analysis, and IgG antibody levels to P. gingivalis were determined by using enzyme-linked immunosorbent assay. Plaque samples were examined for the presence of P. gingivalis by DNA-DNA checkerboard. Data were analyzed on a person-level basis for relationships to serum IgG antibody levels to P. gingivalis and on a site-specific level for relationships to the presence of P. gingivalis in plaque. Results: A majority (77%) of the subjects were systemically healthy, non-white (74%), and did not have detectable P. gingivalis in their plaque. Fifty-two percent of the subjects had positive serum IgG antibody levels to P. gingivalis. Based on univariate linear regression, factors related to IgG antibody levels to P. gingivalis (P2 mm. When all clinical measures were considered together, only age remained statistically significantly related to serum IgG antibody levels to P. gingivalis. Conclusions: Age is one of the most important factors in the development of the immune response to putative microorganisms such as P. gingivalis in children. The role of IgG as a time-sensitive measure of periodontal health in children needs to be investigated further.

Original languageEnglish (US)
Pages (from-to)221-228
Number of pages8
JournalJournal of Periodontology
Volume75
Issue number2
DOIs
StatePublished - Feb 2004

Fingerprint

Porphyromonas gingivalis
Immunoglobulin G
Antibodies
Serum
Dental Plaque
Gingivitis
DNA
Antibody Formation
Linear Models

Keywords

  • Age factors
  • Antibody response
  • Children
  • IgG
  • Immune response
  • Porphyromonas gingivalis

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Donley, C. L., Badovinac, R., Sapir, S., Shapira, L., Houri, Y., Kantarci, A., ... Bimstein, E. (2004). IgG antibody levels to Porphyromonas gingivalis and clinical measures in children. Journal of Periodontology, 75(2), 221-228. https://doi.org/10.1902/jop.2004.75.2.221

IgG antibody levels to Porphyromonas gingivalis and clinical measures in children. / Donley, Cara L.; Badovinac, Rachel; Sapir, Shabtai; Shapira, Lior; Houri, Yael; Kantarci, Alpdogan; Warbington, Martha L.; Dibart, Serge; Van Dyke, Thomas E.; Needleman, Howard L.; Karimbux, Nadeem; Bimstein, Enrique.

In: Journal of Periodontology, Vol. 75, No. 2, 02.2004, p. 221-228.

Research output: Contribution to journalArticle

Donley, CL, Badovinac, R, Sapir, S, Shapira, L, Houri, Y, Kantarci, A, Warbington, ML, Dibart, S, Van Dyke, TE, Needleman, HL, Karimbux, N & Bimstein, E 2004, 'IgG antibody levels to Porphyromonas gingivalis and clinical measures in children', Journal of Periodontology, vol. 75, no. 2, pp. 221-228. https://doi.org/10.1902/jop.2004.75.2.221
Donley CL, Badovinac R, Sapir S, Shapira L, Houri Y, Kantarci A et al. IgG antibody levels to Porphyromonas gingivalis and clinical measures in children. Journal of Periodontology. 2004 Feb;75(2):221-228. https://doi.org/10.1902/jop.2004.75.2.221
Donley, Cara L. ; Badovinac, Rachel ; Sapir, Shabtai ; Shapira, Lior ; Houri, Yael ; Kantarci, Alpdogan ; Warbington, Martha L. ; Dibart, Serge ; Van Dyke, Thomas E. ; Needleman, Howard L. ; Karimbux, Nadeem ; Bimstein, Enrique. / IgG antibody levels to Porphyromonas gingivalis and clinical measures in children. In: Journal of Periodontology. 2004 ; Vol. 75, No. 2. pp. 221-228.
@article{9c0e2ec2c82f4d0883323fc580727f8d,
title = "IgG antibody levels to Porphyromonas gingivalis and clinical measures in children",
abstract = "Background: Periodontopathic clinical markers are poorly understood in the pediatric population. Several studies have proposed Porphyromonas gingivalis (P. gingivalis) and an antibody response to the microorganism as factors in periodontal tissue destruction in children. The objective of this study was to examine the prevalence of P. gingivalis in dental plaque and of serum immunoglobulin G (IgG) antibody levels to P. gingivalis, and their relationship to periodontal clinical measures in children. Methods: Thirty-one subjects, aged 20 to 163 months, participated in this study. Clinical measures examined included gingivitis, plaque, alveolar bone height, age, gender, ethnicity, medical status, caries, and IgG antibody levels to P. gingivalis. Five ml of blood was collected for serum analysis, and IgG antibody levels to P. gingivalis were determined by using enzyme-linked immunosorbent assay. Plaque samples were examined for the presence of P. gingivalis by DNA-DNA checkerboard. Data were analyzed on a person-level basis for relationships to serum IgG antibody levels to P. gingivalis and on a site-specific level for relationships to the presence of P. gingivalis in plaque. Results: A majority (77{\%}) of the subjects were systemically healthy, non-white (74{\%}), and did not have detectable P. gingivalis in their plaque. Fifty-two percent of the subjects had positive serum IgG antibody levels to P. gingivalis. Based on univariate linear regression, factors related to IgG antibody levels to P. gingivalis (P2 mm. When all clinical measures were considered together, only age remained statistically significantly related to serum IgG antibody levels to P. gingivalis. Conclusions: Age is one of the most important factors in the development of the immune response to putative microorganisms such as P. gingivalis in children. The role of IgG as a time-sensitive measure of periodontal health in children needs to be investigated further.",
keywords = "Age factors, Antibody response, Children, IgG, Immune response, Porphyromonas gingivalis",
author = "Donley, {Cara L.} and Rachel Badovinac and Shabtai Sapir and Lior Shapira and Yael Houri and Alpdogan Kantarci and Warbington, {Martha L.} and Serge Dibart and {Van Dyke}, {Thomas E.} and Needleman, {Howard L.} and Nadeem Karimbux and Enrique Bimstein",
year = "2004",
month = "2",
doi = "10.1902/jop.2004.75.2.221",
language = "English (US)",
volume = "75",
pages = "221--228",
journal = "Journal of Periodontology",
issn = "0022-3492",
publisher = "American Academy of Periodontology",
number = "2",

}

TY - JOUR

T1 - IgG antibody levels to Porphyromonas gingivalis and clinical measures in children

AU - Donley, Cara L.

AU - Badovinac, Rachel

AU - Sapir, Shabtai

AU - Shapira, Lior

AU - Houri, Yael

AU - Kantarci, Alpdogan

AU - Warbington, Martha L.

AU - Dibart, Serge

AU - Van Dyke, Thomas E.

AU - Needleman, Howard L.

AU - Karimbux, Nadeem

AU - Bimstein, Enrique

PY - 2004/2

Y1 - 2004/2

N2 - Background: Periodontopathic clinical markers are poorly understood in the pediatric population. Several studies have proposed Porphyromonas gingivalis (P. gingivalis) and an antibody response to the microorganism as factors in periodontal tissue destruction in children. The objective of this study was to examine the prevalence of P. gingivalis in dental plaque and of serum immunoglobulin G (IgG) antibody levels to P. gingivalis, and their relationship to periodontal clinical measures in children. Methods: Thirty-one subjects, aged 20 to 163 months, participated in this study. Clinical measures examined included gingivitis, plaque, alveolar bone height, age, gender, ethnicity, medical status, caries, and IgG antibody levels to P. gingivalis. Five ml of blood was collected for serum analysis, and IgG antibody levels to P. gingivalis were determined by using enzyme-linked immunosorbent assay. Plaque samples were examined for the presence of P. gingivalis by DNA-DNA checkerboard. Data were analyzed on a person-level basis for relationships to serum IgG antibody levels to P. gingivalis and on a site-specific level for relationships to the presence of P. gingivalis in plaque. Results: A majority (77%) of the subjects were systemically healthy, non-white (74%), and did not have detectable P. gingivalis in their plaque. Fifty-two percent of the subjects had positive serum IgG antibody levels to P. gingivalis. Based on univariate linear regression, factors related to IgG antibody levels to P. gingivalis (P2 mm. When all clinical measures were considered together, only age remained statistically significantly related to serum IgG antibody levels to P. gingivalis. Conclusions: Age is one of the most important factors in the development of the immune response to putative microorganisms such as P. gingivalis in children. The role of IgG as a time-sensitive measure of periodontal health in children needs to be investigated further.

AB - Background: Periodontopathic clinical markers are poorly understood in the pediatric population. Several studies have proposed Porphyromonas gingivalis (P. gingivalis) and an antibody response to the microorganism as factors in periodontal tissue destruction in children. The objective of this study was to examine the prevalence of P. gingivalis in dental plaque and of serum immunoglobulin G (IgG) antibody levels to P. gingivalis, and their relationship to periodontal clinical measures in children. Methods: Thirty-one subjects, aged 20 to 163 months, participated in this study. Clinical measures examined included gingivitis, plaque, alveolar bone height, age, gender, ethnicity, medical status, caries, and IgG antibody levels to P. gingivalis. Five ml of blood was collected for serum analysis, and IgG antibody levels to P. gingivalis were determined by using enzyme-linked immunosorbent assay. Plaque samples were examined for the presence of P. gingivalis by DNA-DNA checkerboard. Data were analyzed on a person-level basis for relationships to serum IgG antibody levels to P. gingivalis and on a site-specific level for relationships to the presence of P. gingivalis in plaque. Results: A majority (77%) of the subjects were systemically healthy, non-white (74%), and did not have detectable P. gingivalis in their plaque. Fifty-two percent of the subjects had positive serum IgG antibody levels to P. gingivalis. Based on univariate linear regression, factors related to IgG antibody levels to P. gingivalis (P2 mm. When all clinical measures were considered together, only age remained statistically significantly related to serum IgG antibody levels to P. gingivalis. Conclusions: Age is one of the most important factors in the development of the immune response to putative microorganisms such as P. gingivalis in children. The role of IgG as a time-sensitive measure of periodontal health in children needs to be investigated further.

KW - Age factors

KW - Antibody response

KW - Children

KW - IgG

KW - Immune response

KW - Porphyromonas gingivalis

UR - http://www.scopus.com/inward/record.url?scp=12144290016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12144290016&partnerID=8YFLogxK

U2 - 10.1902/jop.2004.75.2.221

DO - 10.1902/jop.2004.75.2.221

M3 - Article

VL - 75

SP - 221

EP - 228

JO - Journal of Periodontology

JF - Journal of Periodontology

SN - 0022-3492

IS - 2

ER -