IGF-1 and bone: New discoveries from mouse models

Shoshana Yakar, Hayden William Courtland, David Clemmons

Research output: Contribution to journalArticle

Abstract

Insulin-like growth factor-1 (IGF-1) plays a central role in cellular growth, differentiation, survival, and cell cycle progression. It is expressed early during development and its effects are mediated through binding to a tyrosine kinase receptor, the insulin-like growth factor-1 receptor (IGF-1R). In the circulation, the IGFs bind to IGF-binding proteins (IGFBPs), which determine their bioavailability and regulate the interaction between the IGFs and IGF-1R. Studies in animal models and in humans have established critical roles for IGFs in skeletal growth and development. In this review we present new and old findings from mouse models of the IGF system and discuss their clinical relevance to normal and pathological skeletal physiology.

Original languageEnglish (US)
Pages (from-to)2267-2276
Number of pages10
JournalJournal of Bone and Mineral Research
Volume25
Issue number12
DOIs
StatePublished - Dec 2010

Fingerprint

Somatomedin Receptors
Insulin-Like Growth Factor Binding Proteins
Growth Factor Receptors
Somatomedins
Growth and Development
Biological Availability
Cell Cycle
Animal Models
Bone and Bones
Survival
Growth
insulin receptor tyrosine kinase

Keywords

  • Bone Accrual
  • Cortical-Bone
  • Growth Hormone
  • Insulin-Like Growth Factor
  • Skeletal Growth

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

IGF-1 and bone : New discoveries from mouse models. / Yakar, Shoshana; Courtland, Hayden William; Clemmons, David.

In: Journal of Bone and Mineral Research, Vol. 25, No. 12, 12.2010, p. 2267-2276.

Research output: Contribution to journalArticle

Yakar, Shoshana ; Courtland, Hayden William ; Clemmons, David. / IGF-1 and bone : New discoveries from mouse models. In: Journal of Bone and Mineral Research. 2010 ; Vol. 25, No. 12. pp. 2267-2276.
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