Identifying common genetic risk factors of diabetic neuropathies

Ini-Isabee Gunn, Herbert F. Jelinek, Kinda Khalaf, Sungmun Lee, Ahsan H. Khandoker, Habiba Alsafar

Research output: Contribution to journalReview article

Abstract

Type 2 diabetes mellitus (T2DM) is a global public health problem of epidemic proportions, with 60-70% of affected individuals suffering from associated neurovascular complications that act on multiple organ systems. The most common and clinically significant neuropathies of T2DM include uremic neuropathy, peripheral neuropathy, and cardiac autonomic neuropathy. These conditions seriously impact an individual's quality of life and significantly increase the risk of morbidity and mortality. Although advances in gene sequencing technologies have identified several genetic variants that may regulate the development and progression of T2DM, little is known about whether or not the variants are involved in disease progression and how these genetic variants are associated with diabetic neuropathy specifically. Significant missing heritability data and complex disease etiologies remain to be explained. This article is the first to provide a review of the genetic risk variants implicated in the diabetic neuropathies and to highlight potential commonalities. We thereby aim to contribute to the creation of a genetic-metabolic model that will help to elucidate the cause of diabetic neuropathies, evaluate a patient's risk profile, and ultimately facilitate preventative and targeted treatment for the individual.

Original languageEnglish (US)
Article number88
JournalFrontiers in Endocrinology
Volume6
Issue numberMAY
DOIs
StatePublished - Jan 1 2015

Fingerprint

Diabetic Neuropathies
Type 2 Diabetes Mellitus
Genetic Models
Peripheral Nervous System Diseases
Disease Progression
Public Health
Quality of Life
Technology
Morbidity
Mortality
Genes
Therapeutics

Keywords

  • Cardiac autonomic neuropathy
  • Diabetic complications
  • Diabetic neuropathy
  • Diabetic peripheral neuropathy
  • Genetic factors
  • Type 2 diabetes mellitus
  • Uremic neuropathy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Gunn, I-I., Jelinek, H. F., Khalaf, K., Lee, S., Khandoker, A. H., & Alsafar, H. (2015). Identifying common genetic risk factors of diabetic neuropathies. Frontiers in Endocrinology, 6(MAY), [88]. https://doi.org/10.3389/fendo.2015.00088

Identifying common genetic risk factors of diabetic neuropathies. / Gunn, Ini-Isabee; Jelinek, Herbert F.; Khalaf, Kinda; Lee, Sungmun; Khandoker, Ahsan H.; Alsafar, Habiba.

In: Frontiers in Endocrinology, Vol. 6, No. MAY, 88, 01.01.2015.

Research output: Contribution to journalReview article

Gunn, I-I, Jelinek, HF, Khalaf, K, Lee, S, Khandoker, AH & Alsafar, H 2015, 'Identifying common genetic risk factors of diabetic neuropathies', Frontiers in Endocrinology, vol. 6, no. MAY, 88. https://doi.org/10.3389/fendo.2015.00088
Gunn I-I, Jelinek HF, Khalaf K, Lee S, Khandoker AH, Alsafar H. Identifying common genetic risk factors of diabetic neuropathies. Frontiers in Endocrinology. 2015 Jan 1;6(MAY). 88. https://doi.org/10.3389/fendo.2015.00088
Gunn, Ini-Isabee ; Jelinek, Herbert F. ; Khalaf, Kinda ; Lee, Sungmun ; Khandoker, Ahsan H. ; Alsafar, Habiba. / Identifying common genetic risk factors of diabetic neuropathies. In: Frontiers in Endocrinology. 2015 ; Vol. 6, No. MAY.
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