Identification of distinct subgroups of breast cancer patients based on self-reported changes in sleep disturbance

Christina Van Onselen, Bruce A. Cooper, Kathryn Lee, Laura Dunn, Bradley E. Aouizerat, Claudia West, Marylin Dodd, Steven Paul, Christine Miaskowski

Research output: Contribution to journalArticle

Abstract

Purpose The purposes of this study were to identify distinct subgroups of patients based on self-reported sleep disturbance prior to through 6 months after breast cancer surgery and evaluate for differences in demographic, clinical, and symptom characteristics among these latent classes. Methods Women (n0398) who underwent unilateral breast cancer surgery were enrolled prior to surgery. Patients completed measures of functional status, sleep disturbance (i.e., General Sleep Disturbance Scale (GSDS); higher scores indicate higher levels of sleep disturbance), fatigue, attentional fatigue, depressive symptoms, and anxiety prior to surgery and monthly for 6 months. Results Three distinct classes of sleep disturbance trajectories were identified using growth mixture modeling. The high sustained class (55.0%) had high and the low sustained class (39.7%) had low GSDS scores prior to surgery that persisted for 6 months. The decreasing class (5.3%) had high GSDS score prior to surgery that decreased over time. Women in the high sustained class were significantly younger, had more comorbidity and poorer function, and were more likely to report hot flashes compared to the low sustained class. More women who underwent mastectomy or breast reconstruction were in the decreasing class. Decreasing and high sustained classes reported higher levels of physical fatigue, attentional fatigue, depressive symptoms, and anxiety compared to the low sustained class. Conclusions A high percentage of women has significant sleep disturbance prior to surgery that persists during subsequent treatments (i.e., radiation therapy and chemotherapy). Clinicians need to perform routine assessments and initiate appropriate interventions to improve sleep prior to and following surgery.

Original languageEnglish (US)
Pages (from-to)2611-2619
Number of pages9
JournalSupportive Care in Cancer
Volume20
Issue number10
DOIs
StatePublished - Oct 2012

Fingerprint

Sleep
Breast Neoplasms
Fatigue
Anxiety
Depression
Hot Flashes
Mammaplasty
Mastectomy
Comorbidity
Radiotherapy
Demography
Drug Therapy
Growth

Keywords

  • Anxiety
  • Attentional fatigue
  • Breast cancer
  • Depression
  • Fatigue
  • Growth mixture modeling
  • Latent class analysis
  • Sleep disturbance

ASJC Scopus subject areas

  • Oncology

Cite this

Identification of distinct subgroups of breast cancer patients based on self-reported changes in sleep disturbance. / Onselen, Christina Van; Cooper, Bruce A.; Lee, Kathryn; Dunn, Laura; Aouizerat, Bradley E.; West, Claudia; Dodd, Marylin; Paul, Steven; Miaskowski, Christine.

In: Supportive Care in Cancer, Vol. 20, No. 10, 10.2012, p. 2611-2619.

Research output: Contribution to journalArticle

Onselen, Christina Van ; Cooper, Bruce A. ; Lee, Kathryn ; Dunn, Laura ; Aouizerat, Bradley E. ; West, Claudia ; Dodd, Marylin ; Paul, Steven ; Miaskowski, Christine. / Identification of distinct subgroups of breast cancer patients based on self-reported changes in sleep disturbance. In: Supportive Care in Cancer. 2012 ; Vol. 20, No. 10. pp. 2611-2619.
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abstract = "Purpose The purposes of this study were to identify distinct subgroups of patients based on self-reported sleep disturbance prior to through 6 months after breast cancer surgery and evaluate for differences in demographic, clinical, and symptom characteristics among these latent classes. Methods Women (n0398) who underwent unilateral breast cancer surgery were enrolled prior to surgery. Patients completed measures of functional status, sleep disturbance (i.e., General Sleep Disturbance Scale (GSDS); higher scores indicate higher levels of sleep disturbance), fatigue, attentional fatigue, depressive symptoms, and anxiety prior to surgery and monthly for 6 months. Results Three distinct classes of sleep disturbance trajectories were identified using growth mixture modeling. The high sustained class (55.0{\%}) had high and the low sustained class (39.7{\%}) had low GSDS scores prior to surgery that persisted for 6 months. The decreasing class (5.3{\%}) had high GSDS score prior to surgery that decreased over time. Women in the high sustained class were significantly younger, had more comorbidity and poorer function, and were more likely to report hot flashes compared to the low sustained class. More women who underwent mastectomy or breast reconstruction were in the decreasing class. Decreasing and high sustained classes reported higher levels of physical fatigue, attentional fatigue, depressive symptoms, and anxiety compared to the low sustained class. Conclusions A high percentage of women has significant sleep disturbance prior to surgery that persists during subsequent treatments (i.e., radiation therapy and chemotherapy). Clinicians need to perform routine assessments and initiate appropriate interventions to improve sleep prior to and following surgery.",
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N2 - Purpose The purposes of this study were to identify distinct subgroups of patients based on self-reported sleep disturbance prior to through 6 months after breast cancer surgery and evaluate for differences in demographic, clinical, and symptom characteristics among these latent classes. Methods Women (n0398) who underwent unilateral breast cancer surgery were enrolled prior to surgery. Patients completed measures of functional status, sleep disturbance (i.e., General Sleep Disturbance Scale (GSDS); higher scores indicate higher levels of sleep disturbance), fatigue, attentional fatigue, depressive symptoms, and anxiety prior to surgery and monthly for 6 months. Results Three distinct classes of sleep disturbance trajectories were identified using growth mixture modeling. The high sustained class (55.0%) had high and the low sustained class (39.7%) had low GSDS scores prior to surgery that persisted for 6 months. The decreasing class (5.3%) had high GSDS score prior to surgery that decreased over time. Women in the high sustained class were significantly younger, had more comorbidity and poorer function, and were more likely to report hot flashes compared to the low sustained class. More women who underwent mastectomy or breast reconstruction were in the decreasing class. Decreasing and high sustained classes reported higher levels of physical fatigue, attentional fatigue, depressive symptoms, and anxiety compared to the low sustained class. Conclusions A high percentage of women has significant sleep disturbance prior to surgery that persists during subsequent treatments (i.e., radiation therapy and chemotherapy). Clinicians need to perform routine assessments and initiate appropriate interventions to improve sleep prior to and following surgery.

AB - Purpose The purposes of this study were to identify distinct subgroups of patients based on self-reported sleep disturbance prior to through 6 months after breast cancer surgery and evaluate for differences in demographic, clinical, and symptom characteristics among these latent classes. Methods Women (n0398) who underwent unilateral breast cancer surgery were enrolled prior to surgery. Patients completed measures of functional status, sleep disturbance (i.e., General Sleep Disturbance Scale (GSDS); higher scores indicate higher levels of sleep disturbance), fatigue, attentional fatigue, depressive symptoms, and anxiety prior to surgery and monthly for 6 months. Results Three distinct classes of sleep disturbance trajectories were identified using growth mixture modeling. The high sustained class (55.0%) had high and the low sustained class (39.7%) had low GSDS scores prior to surgery that persisted for 6 months. The decreasing class (5.3%) had high GSDS score prior to surgery that decreased over time. Women in the high sustained class were significantly younger, had more comorbidity and poorer function, and were more likely to report hot flashes compared to the low sustained class. More women who underwent mastectomy or breast reconstruction were in the decreasing class. Decreasing and high sustained classes reported higher levels of physical fatigue, attentional fatigue, depressive symptoms, and anxiety compared to the low sustained class. Conclusions A high percentage of women has significant sleep disturbance prior to surgery that persists during subsequent treatments (i.e., radiation therapy and chemotherapy). Clinicians need to perform routine assessments and initiate appropriate interventions to improve sleep prior to and following surgery.

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