Identification of a novel HLA-A allele, HLA-A01

195, in a UAE national

Wael Abdrabou, Ini-Isabee Gunn, Agnieszka Paduch, Guan Tay, Habiba Alsafar

Research output: Contribution to journalArticle

Abstract

A novel human leucocyte antigen (HLA)-A allele, HLA-A01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine.

Original languageEnglish (US)
Pages (from-to)605-608
Number of pages4
JournalHuman Immunology
Volume77
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

HLA Antigens
Alleles
Exons
Mutation
Isoleucine
Valine
Codon
Nucleotides
Amino Acids
Proteins

Keywords

  • Arab genetics
  • HLA-A01:195
  • Novel HLA-A allele
  • Sequence based typing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Abdrabou, W., Gunn, I-I., Paduch, A., Tay, G., & Alsafar, H. (2016). Identification of a novel HLA-A allele, HLA-A01: 195, in a UAE national. Human Immunology, 77(7), 605-608. https://doi.org/10.1016/j.humimm.2016.05.010

Identification of a novel HLA-A allele, HLA-A01 : 195, in a UAE national. / Abdrabou, Wael; Gunn, Ini-Isabee; Paduch, Agnieszka; Tay, Guan; Alsafar, Habiba.

In: Human Immunology, Vol. 77, No. 7, 01.07.2016, p. 605-608.

Research output: Contribution to journalArticle

Abdrabou, W, Gunn, I-I, Paduch, A, Tay, G & Alsafar, H 2016, 'Identification of a novel HLA-A allele, HLA-A01: 195, in a UAE national', Human Immunology, vol. 77, no. 7, pp. 605-608. https://doi.org/10.1016/j.humimm.2016.05.010
Abdrabou, Wael ; Gunn, Ini-Isabee ; Paduch, Agnieszka ; Tay, Guan ; Alsafar, Habiba. / Identification of a novel HLA-A allele, HLA-A01 : 195, in a UAE national. In: Human Immunology. 2016 ; Vol. 77, No. 7. pp. 605-608.
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