Hyperglycemia and Cancer: A State-of-the-Science Review

Marilyn Hammer, Susan Storey, Denise S. Hershey, Veronica J. Brady, Ellen Davis, Natalie Mandolfo, Ashley L. Bryant, Jill Olausson

Research output: Contribution to journalArticle

Abstract

PROBLEM IDENTIFICATION: Hyperglycemia can increase the risk for adverse events and outcomes in patients undergoing treatment for cancer. The purposes of this state-of-the-science review were to explore the complexity of hyperglycemia in patients with cancer and to analyze physiologic mechanisms and outcomes in individuals with or at risk for cancer. LITERATURE SEARCH: PubMed® and the Cochrane Library databases were searched, and 95 articles were included. Findings were evaluated for their methods and analyses. Studies assessed as methodologically flawed were not included. DATA EVALUATION: The synthesis of the articles provided the evidence for describing normal and glycemic pathways. Hyperglycemia in patients with cancer was explored through chronic inflammatory mechanisms that lead to increased risks for adverse events and outcomes. SYNTHESIS: This article discusses normal glucose regulation and hyperglycemic pathways, hyperglycemia in patients with cancer, hyperglycemia and cancer-related inflammation, and outcomes (e.g., infections, mortality, symptoms). IMPLICATIONS FOR RESEARCH: Understanding the contributors to and consequences of hyperglycemia can guide the development of screening tools to predict which individuals are at the greatest risk for hyperglycemic episodes prior to starting cancer therapies. Research can lead to glycemic guidelines specific to patients with cancer for better outcomes.

Original languageEnglish (US)
Pages (from-to)459-472
Number of pages14
JournalOncology nursing forum
Volume46
Issue number4
DOIs
StatePublished - Jul 1 2019

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Hyperglycemia
Neoplasms
PubMed
Libraries
Databases
Guidelines
Inflammation
Glucose
Mortality
Therapeutics
Infection
Research

Keywords

  • blood glucose
  • immune function
  • infections
  • inflammation
  • mortality
  • organ dysfunction

ASJC Scopus subject areas

  • Oncology(nursing)

Cite this

Hammer, M., Storey, S., Hershey, D. S., Brady, V. J., Davis, E., Mandolfo, N., ... Olausson, J. (2019). Hyperglycemia and Cancer: A State-of-the-Science Review. Oncology nursing forum, 46(4), 459-472. https://doi.org/10.1188/19.ONF.459-472

Hyperglycemia and Cancer : A State-of-the-Science Review. / Hammer, Marilyn; Storey, Susan; Hershey, Denise S.; Brady, Veronica J.; Davis, Ellen; Mandolfo, Natalie; Bryant, Ashley L.; Olausson, Jill.

In: Oncology nursing forum, Vol. 46, No. 4, 01.07.2019, p. 459-472.

Research output: Contribution to journalArticle

Hammer, M, Storey, S, Hershey, DS, Brady, VJ, Davis, E, Mandolfo, N, Bryant, AL & Olausson, J 2019, 'Hyperglycemia and Cancer: A State-of-the-Science Review', Oncology nursing forum, vol. 46, no. 4, pp. 459-472. https://doi.org/10.1188/19.ONF.459-472
Hammer M, Storey S, Hershey DS, Brady VJ, Davis E, Mandolfo N et al. Hyperglycemia and Cancer: A State-of-the-Science Review. Oncology nursing forum. 2019 Jul 1;46(4):459-472. https://doi.org/10.1188/19.ONF.459-472
Hammer, Marilyn ; Storey, Susan ; Hershey, Denise S. ; Brady, Veronica J. ; Davis, Ellen ; Mandolfo, Natalie ; Bryant, Ashley L. ; Olausson, Jill. / Hyperglycemia and Cancer : A State-of-the-Science Review. In: Oncology nursing forum. 2019 ; Vol. 46, No. 4. pp. 459-472.
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