Hyaluronidase activity during open wound healing in rabbits

A preliminary report

Charles Bertolami, R. Bruce Donoff

Research output: Contribution to journalArticle

Abstract

The presence of an enzyme with hyaluronidase activity has been established for open wound granulation tissue in rabbits. Such activity was unrelated to the presence of inflammatory cells and, in fact, was absent in early wounds. Activity increased 7 days after wounding and remained elevated through the 19-day term of the study. The approximate hyaluronic acid content of granulation tissue during healing decreased markedly during this period. The relationship of hyaluronidase to hyaluronic acid in the process of open would healing is discussed.

Original languageEnglish (US)
Pages (from-to)256-259
Number of pages4
JournalJournal of Surgical Research
Volume25
Issue number3
DOIs
StatePublished - 1978

Fingerprint

Hyaluronoglucosaminidase
Granulation Tissue
Hyaluronic Acid
Wound Healing
Rabbits
Wounds and Injuries
Enzymes

ASJC Scopus subject areas

  • Surgery

Cite this

Hyaluronidase activity during open wound healing in rabbits : A preliminary report. / Bertolami, Charles; Donoff, R. Bruce.

In: Journal of Surgical Research, Vol. 25, No. 3, 1978, p. 256-259.

Research output: Contribution to journalArticle

@article{70542981466744a69384f3aabd2ee832,
title = "Hyaluronidase activity during open wound healing in rabbits: A preliminary report",
abstract = "The presence of an enzyme with hyaluronidase activity has been established for open wound granulation tissue in rabbits. Such activity was unrelated to the presence of inflammatory cells and, in fact, was absent in early wounds. Activity increased 7 days after wounding and remained elevated through the 19-day term of the study. The approximate hyaluronic acid content of granulation tissue during healing decreased markedly during this period. The relationship of hyaluronidase to hyaluronic acid in the process of open would healing is discussed.",
author = "Charles Bertolami and Donoff, {R. Bruce}",
year = "1978",
doi = "10.1016/0022-4804(78)90116-6",
language = "English (US)",
volume = "25",
pages = "256--259",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Hyaluronidase activity during open wound healing in rabbits

T2 - A preliminary report

AU - Bertolami, Charles

AU - Donoff, R. Bruce

PY - 1978

Y1 - 1978

N2 - The presence of an enzyme with hyaluronidase activity has been established for open wound granulation tissue in rabbits. Such activity was unrelated to the presence of inflammatory cells and, in fact, was absent in early wounds. Activity increased 7 days after wounding and remained elevated through the 19-day term of the study. The approximate hyaluronic acid content of granulation tissue during healing decreased markedly during this period. The relationship of hyaluronidase to hyaluronic acid in the process of open would healing is discussed.

AB - The presence of an enzyme with hyaluronidase activity has been established for open wound granulation tissue in rabbits. Such activity was unrelated to the presence of inflammatory cells and, in fact, was absent in early wounds. Activity increased 7 days after wounding and remained elevated through the 19-day term of the study. The approximate hyaluronic acid content of granulation tissue during healing decreased markedly during this period. The relationship of hyaluronidase to hyaluronic acid in the process of open would healing is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0018128997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018128997&partnerID=8YFLogxK

U2 - 10.1016/0022-4804(78)90116-6

DO - 10.1016/0022-4804(78)90116-6

M3 - Article

VL - 25

SP - 256

EP - 259

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 3

ER -