Human parietal cortex lesions impact the precision of spatial working memory

Wayne E. Mackey, Orrin Devinsky, Werner K. Doyle, John G. Golfinos, Clayton Curtis

Research output: Contribution to journalArticle

Abstract

The neural mechanisms that support working memory (WM) depend on persistent neural activity. Within topographically organized maps of space in dorsal parietal cortex, spatially selective neural activity persists during WM for location. However, to date, the necessity of these topographic subregions of human parietal cortex for WM remains unknown. To test the causal relationship of these areas to WM, we compared the performance of patients with lesions to topographically organized parietal cortex with those of controls on a memory-guided saccade (MGS) task as well as a visually guided saccade (VGS) task. The MGS task allowed us to measure WM precision continuously with great sensitivity, whereas the VGS task allowed us to control for any deficits in general spatial or visuomotor processing. Compared with controls, patients generated memory-guided saccades that were significantly slower and less accurate, whereas visually guided saccades were unaffected. These results provide key missing evidence for the causal role of topographic areas in human parietal cortex for WM, as well as the neural mechanisms supporting WM.

Original languageEnglish (US)
Pages (from-to)1049-1054
Number of pages6
JournalJournal of Neurophysiology
Volume116
Issue number3
DOIs
StatePublished - Sep 1 2016

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Parietal Lobe
Saccades
Short-Term Memory
Spatial Memory

Keywords

  • Intraparietal sulcus
  • Lesion
  • Posterior parietal cortex
  • Saccade
  • Topography
  • Working memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Medicine(all)

Cite this

Human parietal cortex lesions impact the precision of spatial working memory. / Mackey, Wayne E.; Devinsky, Orrin; Doyle, Werner K.; Golfinos, John G.; Curtis, Clayton.

In: Journal of Neurophysiology, Vol. 116, No. 3, 01.09.2016, p. 1049-1054.

Research output: Contribution to journalArticle

Mackey, Wayne E. ; Devinsky, Orrin ; Doyle, Werner K. ; Golfinos, John G. ; Curtis, Clayton. / Human parietal cortex lesions impact the precision of spatial working memory. In: Journal of Neurophysiology. 2016 ; Vol. 116, No. 3. pp. 1049-1054.
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