Human milk hyaluronan enhances innate defense of the intestinal epithelium

David R. Hill, Hyunjin K. Rho, Sean P. Kessler, Ripal Amin, Craig R. Homer, Christine McDonald, Mary Cowman, Carol A. De La Motte

Research output: Contribution to journalArticle

Abstract

Background:Human milk contains hyaluronan (HA). Results:Milk HA concentration is highest immediately after delivery. Treatment of epithelium with physiologic levels of milk-derived HA increases intracellular expression of-defensin (in vitroandin vivo) and resistance toSalmonella. Conclusion:Milk HA enhances functional antimicrobial defense mechanisms of the intestinal epithelium. Significance:Milk HA may be a mediator of maternal protection of newborns.

Original languageEnglish (US)
Pages (from-to)29090-29104
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
StatePublished - Oct 4 2013

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Human Milk
Hyaluronic Acid
Intestinal Mucosa
Milk
Defensins
Epithelium
Mothers

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Hill, D. R., Rho, H. K., Kessler, S. P., Amin, R., Homer, C. R., McDonald, C., ... De La Motte, C. A. (2013). Human milk hyaluronan enhances innate defense of the intestinal epithelium. Journal of Biological Chemistry, 288(40), 29090-29104. https://doi.org/10.1074/jbc.M113.468629

Human milk hyaluronan enhances innate defense of the intestinal epithelium. / Hill, David R.; Rho, Hyunjin K.; Kessler, Sean P.; Amin, Ripal; Homer, Craig R.; McDonald, Christine; Cowman, Mary; De La Motte, Carol A.

In: Journal of Biological Chemistry, Vol. 288, No. 40, 04.10.2013, p. 29090-29104.

Research output: Contribution to journalArticle

Hill, DR, Rho, HK, Kessler, SP, Amin, R, Homer, CR, McDonald, C, Cowman, M & De La Motte, CA 2013, 'Human milk hyaluronan enhances innate defense of the intestinal epithelium', Journal of Biological Chemistry, vol. 288, no. 40, pp. 29090-29104. https://doi.org/10.1074/jbc.M113.468629
Hill DR, Rho HK, Kessler SP, Amin R, Homer CR, McDonald C et al. Human milk hyaluronan enhances innate defense of the intestinal epithelium. Journal of Biological Chemistry. 2013 Oct 4;288(40):29090-29104. https://doi.org/10.1074/jbc.M113.468629
Hill, David R. ; Rho, Hyunjin K. ; Kessler, Sean P. ; Amin, Ripal ; Homer, Craig R. ; McDonald, Christine ; Cowman, Mary ; De La Motte, Carol A. / Human milk hyaluronan enhances innate defense of the intestinal epithelium. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 40. pp. 29090-29104.
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