Hsp90 depletion goes wild.

Mark Siegal, Joanna Masel

Research output: Contribution to journalArticle

Abstract

Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation. See research article http://wwww.biomedcentral.com/1471-2148/12/25.

Original languageEnglish (US)
Pages (from-to)14
Number of pages1
JournalBMC Biology
Volume10
DOIs
StatePublished - 2012

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genetic variation
Down-Regulation
DNA Transposable Elements
evolutionary biology
aneuploidy
Aneuploidy
phenotypic variation
transposons
Drosophila
allele
Alleles
alleles
Biological Sciences
Research
laboratory

ASJC Scopus subject areas

  • Physiology
  • Biotechnology
  • Structural Biology
  • Developmental Biology
  • Plant Science
  • Ecology, Evolution, Behavior and Systematics
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Hsp90 depletion goes wild. / Siegal, Mark; Masel, Joanna.

In: BMC Biology, Vol. 10, 2012, p. 14.

Research output: Contribution to journalArticle

Siegal, Mark ; Masel, Joanna. / Hsp90 depletion goes wild. In: BMC Biology. 2012 ; Vol. 10. pp. 14.
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