How vestibular neurons solve the tilt/translation ambiguity: Comparison of brainstem, cerebellum, and thalamus

Dora Angelaki, Tatyana A. Yakusheva

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The peripheral vestibular system is faced by a sensory ambiguity, where primary otolith afferents respond identically to translational (inertial) accelerations and changes in head orientation relative to gravity. Under certain conditions, this sensory ambiguity can be resolved using extra-otolith cues, including semicircular canal signals. Here we review and summarize how neurons in the vestibular nuclei, rostral fastigial nuclei, cerebellar nodulus/uvula, and thalamus respond during combinations of tilt and translation. We focus primarily on cerebellar cortex responses, as nodulus/uvula Purkinje cells reliably encode translation rather than net gravito-inertial acceleration. In contrast, neurons in the vestibular and rostral fastigial nuclei, as well as the ventral lateral and ventral posterior nuclei of the thalamus represent a continuum, with some encoding translation and some net gravito-inertial acceleration. This review also outlines how Purkinje cells use semicircular canal signals to solve the ambiguity problem and how this solution fails at low frequencies. We conclude by attempting to bridge the gap between the proposed roles of nodulus/uvula in tilt/translation discrimination and velocity storage.

Original languageEnglish (US)
Title of host publicationBasic and Clinical Aspects of Vertigo and Dizziness
PublisherBlackwell Publishing Inc.
Pages19-28
Number of pages10
ISBN (Print)9781573317177
DOIs
StatePublished - Jan 1 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1164
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Fingerprint

Uvula
Thalamus
Cerebellum
Brain Stem
Neurons
Ventral Thalamic Nuclei
Otolithic Membrane
Cerebellar Nuclei
Semicircular Canals
Purkinje Cells
Canals
Lateral Thalamic Nuclei
Vestibular Nuclei
Cerebellar Cortex
Gravitation
Cues
Head
Neuron
Nucleus
Cells

Keywords

  • Cerebellum
  • Linear acceleration
  • Purkinje cell
  • Rotation
  • Translation
  • Velocity storage
  • Vermis
  • Vestibular

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Angelaki, D., & Yakusheva, T. A. (2009). How vestibular neurons solve the tilt/translation ambiguity: Comparison of brainstem, cerebellum, and thalamus. In Basic and Clinical Aspects of Vertigo and Dizziness (pp. 19-28). (Annals of the New York Academy of Sciences; Vol. 1164). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.03939.x

How vestibular neurons solve the tilt/translation ambiguity : Comparison of brainstem, cerebellum, and thalamus. / Angelaki, Dora; Yakusheva, Tatyana A.

Basic and Clinical Aspects of Vertigo and Dizziness. Blackwell Publishing Inc., 2009. p. 19-28 (Annals of the New York Academy of Sciences; Vol. 1164).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Angelaki, D & Yakusheva, TA 2009, How vestibular neurons solve the tilt/translation ambiguity: Comparison of brainstem, cerebellum, and thalamus. in Basic and Clinical Aspects of Vertigo and Dizziness. Annals of the New York Academy of Sciences, vol. 1164, Blackwell Publishing Inc., pp. 19-28. https://doi.org/10.1111/j.1749-6632.2009.03939.x
Angelaki D, Yakusheva TA. How vestibular neurons solve the tilt/translation ambiguity: Comparison of brainstem, cerebellum, and thalamus. In Basic and Clinical Aspects of Vertigo and Dizziness. Blackwell Publishing Inc. 2009. p. 19-28. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2009.03939.x
Angelaki, Dora ; Yakusheva, Tatyana A. / How vestibular neurons solve the tilt/translation ambiguity : Comparison of brainstem, cerebellum, and thalamus. Basic and Clinical Aspects of Vertigo and Dizziness. Blackwell Publishing Inc., 2009. pp. 19-28 (Annals of the New York Academy of Sciences).
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