How two meters of DNA fit into a cell nucleus: Polymer models with topological constraints and experimental data

A. Yu Grosberg

    Research output: Contribution to journalArticle

    Abstract

    A recent experiment has confirmed the theoretical prediction of the fractal properties of DNA packaged in the cell nucleus of eukaryotes, particularly in interphase chromosomes. In this study, both the main theoretical ideas and the experimental results are presented in a compact form. Other properties of chromosomes, that is, the so-called territories, which allow for a natural explanation through the concepts of polymer physics, are discussed. At the end, some open questions are formulated.

    Original languageEnglish (US)
    Pages (from-to)1-10
    Number of pages10
    JournalPolymer Science - Series C
    Volume54
    Issue number1
    DOIs
    StatePublished - Sep 2012

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    Chromosomes
    Polymers
    DNA
    Cells
    Fractals
    Physics
    Experiments

    ASJC Scopus subject areas

    • Polymers and Plastics
    • Materials Chemistry
    • Chemistry(all)

    Cite this

    How two meters of DNA fit into a cell nucleus : Polymer models with topological constraints and experimental data. / Grosberg, A. Yu.

    In: Polymer Science - Series C, Vol. 54, No. 1, 09.2012, p. 1-10.

    Research output: Contribution to journalArticle

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