Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors

Mathias F. Wernet, Thomas Labhart, Franziska Baumann, Esteban O. Mazzoni, Franck Pichaud, Claude Desplan

Research output: Contribution to journalArticle

Abstract

Different classes of photoreceptors (PRs) allow animals to perceive various types of visual information. In the Drosophila eye, the outer PRs of each ommatidium are involved in motion detection while the inner PRs mediate color vision. In addition, flies use a specialized class of inner PRs in the "dorsal rim area" of the eye (DRA) to detect the e-vector of polarized light, allowing them to exploit skylight polarization for orientation. We show that homothorax is both necessary and sufficient for inner PRs to adopt the polarization-sensitive DRA fate instead of the color-sensitive default state. Homothorax increases rhabdomere size and uncouples R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision. Homothorax expression is induced by the iroquois complex and the wingless (wg) pathway. However, crucial wg pathway components are not required, suggesting that additional signals are involved.

Original languageEnglish (US)
Pages (from-to)267-279
Number of pages13
JournalCell
Volume115
Issue number3
DOIs
StatePublished - Oct 31 2003

Fingerprint

Color vision
Light polarization
Drosophila
Color Vision
Color
Switches
Polarization
Opsins
Light
Sensors
Animals
Diptera
Communication

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors. / Wernet, Mathias F.; Labhart, Thomas; Baumann, Franziska; Mazzoni, Esteban O.; Pichaud, Franck; Desplan, Claude.

In: Cell, Vol. 115, No. 3, 31.10.2003, p. 267-279.

Research output: Contribution to journalArticle

Wernet, Mathias F. ; Labhart, Thomas ; Baumann, Franziska ; Mazzoni, Esteban O. ; Pichaud, Franck ; Desplan, Claude. / Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors. In: Cell. 2003 ; Vol. 115, No. 3. pp. 267-279.
@article{6d09beb996174fb08e475ca783bf6326,
title = "Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors",
abstract = "Different classes of photoreceptors (PRs) allow animals to perceive various types of visual information. In the Drosophila eye, the outer PRs of each ommatidium are involved in motion detection while the inner PRs mediate color vision. In addition, flies use a specialized class of inner PRs in the {"}dorsal rim area{"} of the eye (DRA) to detect the e-vector of polarized light, allowing them to exploit skylight polarization for orientation. We show that homothorax is both necessary and sufficient for inner PRs to adopt the polarization-sensitive DRA fate instead of the color-sensitive default state. Homothorax increases rhabdomere size and uncouples R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision. Homothorax expression is induced by the iroquois complex and the wingless (wg) pathway. However, crucial wg pathway components are not required, suggesting that additional signals are involved.",
author = "Wernet, {Mathias F.} and Thomas Labhart and Franziska Baumann and Mazzoni, {Esteban O.} and Franck Pichaud and Claude Desplan",
year = "2003",
month = "10",
day = "31",
doi = "10.1016/S0092-8674(03)00848-1",
language = "English (US)",
volume = "115",
pages = "267--279",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors

AU - Wernet, Mathias F.

AU - Labhart, Thomas

AU - Baumann, Franziska

AU - Mazzoni, Esteban O.

AU - Pichaud, Franck

AU - Desplan, Claude

PY - 2003/10/31

Y1 - 2003/10/31

N2 - Different classes of photoreceptors (PRs) allow animals to perceive various types of visual information. In the Drosophila eye, the outer PRs of each ommatidium are involved in motion detection while the inner PRs mediate color vision. In addition, flies use a specialized class of inner PRs in the "dorsal rim area" of the eye (DRA) to detect the e-vector of polarized light, allowing them to exploit skylight polarization for orientation. We show that homothorax is both necessary and sufficient for inner PRs to adopt the polarization-sensitive DRA fate instead of the color-sensitive default state. Homothorax increases rhabdomere size and uncouples R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision. Homothorax expression is induced by the iroquois complex and the wingless (wg) pathway. However, crucial wg pathway components are not required, suggesting that additional signals are involved.

AB - Different classes of photoreceptors (PRs) allow animals to perceive various types of visual information. In the Drosophila eye, the outer PRs of each ommatidium are involved in motion detection while the inner PRs mediate color vision. In addition, flies use a specialized class of inner PRs in the "dorsal rim area" of the eye (DRA) to detect the e-vector of polarized light, allowing them to exploit skylight polarization for orientation. We show that homothorax is both necessary and sufficient for inner PRs to adopt the polarization-sensitive DRA fate instead of the color-sensitive default state. Homothorax increases rhabdomere size and uncouples R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision. Homothorax expression is induced by the iroquois complex and the wingless (wg) pathway. However, crucial wg pathway components are not required, suggesting that additional signals are involved.

UR - http://www.scopus.com/inward/record.url?scp=0242495890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242495890&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(03)00848-1

DO - 10.1016/S0092-8674(03)00848-1

M3 - Article

VL - 115

SP - 267

EP - 279

JO - Cell

JF - Cell

SN - 0092-8674

IS - 3

ER -