Homology model building of the thyroid transcription factor 1 homeodomain

F. Fogolari, Gennaro Esposito, P. Viglino, G. Damante, A. Pastore

    Research output: Contribution to journalArticle

    Abstract

    A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.

    Original languageEnglish (US)
    Pages (from-to)513-519
    Number of pages7
    JournalProtein Engineering, Design and Selection
    Volume6
    Issue number5
    DOIs
    StatePublished - Jul 1 1993

    Fingerprint

    Transcription factors
    X ray crystallography
    Structural Models
    X Ray Crystallography
    Rats
    DNA
    Research Personnel
    thyroid nuclear factor 1

    Keywords

    • 3-D structure
    • Homeodomain
    • Homology modeling
    • Transcription factor

    ASJC Scopus subject areas

    • Biotechnology
    • Bioengineering
    • Medicine(all)
    • Biochemistry
    • Molecular Biology

    Cite this

    Homology model building of the thyroid transcription factor 1 homeodomain. / Fogolari, F.; Esposito, Gennaro; Viglino, P.; Damante, G.; Pastore, A.

    In: Protein Engineering, Design and Selection, Vol. 6, No. 5, 01.07.1993, p. 513-519.

    Research output: Contribution to journalArticle

    Fogolari, F, Esposito, G, Viglino, P, Damante, G & Pastore, A 1993, 'Homology model building of the thyroid transcription factor 1 homeodomain', Protein Engineering, Design and Selection, vol. 6, no. 5, pp. 513-519. https://doi.org/10.1093/protein/6.5.513
    Fogolari, F. ; Esposito, Gennaro ; Viglino, P. ; Damante, G. ; Pastore, A. / Homology model building of the thyroid transcription factor 1 homeodomain. In: Protein Engineering, Design and Selection. 1993 ; Vol. 6, No. 5. pp. 513-519.
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