Homology model building of the thyroid transcription factor 1 homeodomain

F. Fogolari, Gennaro Esposito, P. Viglino, G. Damante, A. Pastore

Research output: Contribution to journalArticle

Abstract

A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.

Original languageEnglish (US)
Pages (from-to)513-519
Number of pages7
JournalProtein Engineering, Design and Selection
Volume6
Issue number5
DOIs
StatePublished - Jul 1 1993

Fingerprint

Transcription factors
X ray crystallography
Structural Models
X Ray Crystallography
Rats
DNA
Research Personnel
thyroid nuclear factor 1

Keywords

  • 3-D structure
  • Homeodomain
  • Homology modeling
  • Transcription factor

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine(all)
  • Biochemistry
  • Molecular Biology

Cite this

Homology model building of the thyroid transcription factor 1 homeodomain. / Fogolari, F.; Esposito, Gennaro; Viglino, P.; Damante, G.; Pastore, A.

In: Protein Engineering, Design and Selection, Vol. 6, No. 5, 01.07.1993, p. 513-519.

Research output: Contribution to journalArticle

Fogolari, F. ; Esposito, Gennaro ; Viglino, P. ; Damante, G. ; Pastore, A. / Homology model building of the thyroid transcription factor 1 homeodomain. In: Protein Engineering, Design and Selection. 1993 ; Vol. 6, No. 5. pp. 513-519.
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