Homeostasis of eye growth and the question of myopia

Josh Wallman, Jonathan Winawer

Research output: Contribution to journalReview article

Abstract

As with other organs, the eye's growth is regulated by homeostatic control mechanisms. Unlike other organs, the eye relies on vision as a principal input to guide growth. In this review, we consider several implications of this visual guidance. First, we compare the regulation of eye growth to that of other organs. Second, we ask how the visual system derives signals that distinguish the blur of an eye too large from one too small. Third, we ask what cascade of chemical signals constitutes this growth control system. Finally, if the match between the length and optics of the eye is under homeostatic control, why do children so commonly develop myopia, and why does the myopia not limit itself? Long-neglected studies may provide an answer to this last question.

Original languageEnglish (US)
Pages (from-to)447-468
Number of pages22
JournalNeuron
Volume43
Issue number4
DOIs
StatePublished - Aug 19 2004

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ASJC Scopus subject areas

  • Neuroscience(all)

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