HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype

Erin E. Sundermann, Jeffrey R. Bishop, Leah H. Rubin, Bradley Aouizerat, Tracey E. Wilson, Kathleen M. Weber, Mardge Cohen, Elizabeth Golub, Kathryn Anastos, Chenglong Liu, Howard Crystal, Celeste L. Pearce, Pauline M. Maki

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women. DESIGN: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women. METHODS: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS. RESULTS: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Z = -3.60, P 

Original languageEnglish (US)
Pages (from-to)1779-1782
Number of pages4
JournalAIDS
Volume27
Issue number11
DOIs
StatePublished - Jul 17 2013

Fingerprint

Catechol O-Methyltransferase
Genotype
HIV
Alleles
Unsafe Sex
Street Drugs
Risk-Taking
Longitudinal Studies
Dopamine
Cohort Studies
Cross-Sectional Studies
Logistic Models

Keywords

  • COMT genotype
  • dopamine
  • HIV risk
  • risk behavior
  • Val158Met

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Sundermann, E. E., Bishop, J. R., Rubin, L. H., Aouizerat, B., Wilson, T. E., Weber, K. M., ... Maki, P. M. (2013). HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype. AIDS, 27(11), 1779-1782. https://doi.org/10.1097/QAD.0b013e328361c6a1

HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype. / Sundermann, Erin E.; Bishop, Jeffrey R.; Rubin, Leah H.; Aouizerat, Bradley; Wilson, Tracey E.; Weber, Kathleen M.; Cohen, Mardge; Golub, Elizabeth; Anastos, Kathryn; Liu, Chenglong; Crystal, Howard; Pearce, Celeste L.; Maki, Pauline M.

In: AIDS, Vol. 27, No. 11, 17.07.2013, p. 1779-1782.

Research output: Contribution to journalArticle

Sundermann, EE, Bishop, JR, Rubin, LH, Aouizerat, B, Wilson, TE, Weber, KM, Cohen, M, Golub, E, Anastos, K, Liu, C, Crystal, H, Pearce, CL & Maki, PM 2013, 'HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype', AIDS, vol. 27, no. 11, pp. 1779-1782. https://doi.org/10.1097/QAD.0b013e328361c6a1
Sundermann EE, Bishop JR, Rubin LH, Aouizerat B, Wilson TE, Weber KM et al. HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype. AIDS. 2013 Jul 17;27(11):1779-1782. https://doi.org/10.1097/QAD.0b013e328361c6a1
Sundermann, Erin E. ; Bishop, Jeffrey R. ; Rubin, Leah H. ; Aouizerat, Bradley ; Wilson, Tracey E. ; Weber, Kathleen M. ; Cohen, Mardge ; Golub, Elizabeth ; Anastos, Kathryn ; Liu, Chenglong ; Crystal, Howard ; Pearce, Celeste L. ; Maki, Pauline M. / HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype. In: AIDS. 2013 ; Vol. 27, No. 11. pp. 1779-1782.
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