Abstract
OBJECTIVE: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women. DESIGN: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women. METHODS: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS. RESULTS: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Z = -3.60, P 
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1779-1782 |
| Number of pages | 4 |
| Journal | AIDS |
| Volume | 27 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jul 17 2013 |
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Keywords
- COMT genotype
- dopamine
- HIV risk
- risk behavior
- Val158Met
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases
Cite this
HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype. / Sundermann, Erin E.; Bishop, Jeffrey R.; Rubin, Leah H.; Aouizerat, Bradley; Wilson, Tracey E.; Weber, Kathleen M.; Cohen, Mardge; Golub, Elizabeth; Anastos, Kathryn; Liu, Chenglong; Crystal, Howard; Pearce, Celeste L.; Maki, Pauline M.
In: AIDS, Vol. 27, No. 11, 17.07.2013, p. 1779-1782.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype
AU - Sundermann, Erin E.
AU - Bishop, Jeffrey R.
AU - Rubin, Leah H.
AU - Aouizerat, Bradley
AU - Wilson, Tracey E.
AU - Weber, Kathleen M.
AU - Cohen, Mardge
AU - Golub, Elizabeth
AU - Anastos, Kathryn
AU - Liu, Chenglong
AU - Crystal, Howard
AU - Pearce, Celeste L.
AU - Maki, Pauline M.
PY - 2013/7/17
Y1 - 2013/7/17
N2 - OBJECTIVE: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women. DESIGN: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women. METHODS: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS. RESULTS: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Z = -3.60, P 
AB - OBJECTIVE: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women. DESIGN: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women. METHODS: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS. RESULTS: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Z = -3.60, P 
KW - COMT genotype
KW - dopamine
KW - HIV risk
KW - risk behavior
KW - Val158Met
UR - http://www.scopus.com/inward/record.url?scp=84879873718&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879873718&partnerID=8YFLogxK
U2 - 10.1097/QAD.0b013e328361c6a1
DO - 10.1097/QAD.0b013e328361c6a1
M3 - Article
C2 - 23807274
AN - SCOPUS:84879873718
VL - 27
SP - 1779
EP - 1782
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 11
ER -