HIV infection affects streptococcus mutans levels, but not genotypes

G. Liu, Deepak Saxena, Z. Chen, R. G. Norman, J. A. Phelan, M. Laverty, G. S. Fisch, P. M. Corby, W. Abrams, Daniel Malamud, Yihong Li

Research output: Contribution to journalArticle

Abstract

We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventional culture methods. The genotype of S. mutans was compared between 10 HIV-positive individuals before and after highly active antiretroviral therapy (HAART) and 10 non-HIV-infected control individuals. The results were analyzed against viral load, CD4+ and CD8+ T-cell counts, salivary flow rate, and caries status. We observed that S. mutans levels were higher in HIV-infected individuals than in the non-HIV-infected control individuals (p = 0.013). No significant differences in S. mutans genotypes were found between the two groups over the six-month study period, even after HAART. There was a bivariate linear relationship between S. mutans levels and CD8+ counts (r = 0.412; p = 0.007), but not between S. mutans levels and either CD4+ counts or viral load. Furthermore, compared with non-HIV-infected control individuals, HIV-infected individuals experienced lower salivary secretion (p = 0.009) and a positive trend toward more decayed tooth surfaces (p = 0.027). These findings suggest that HIV infection can have a significant effect on the level of S. mutans, but not genotypes.

Original languageEnglish (US)
Pages (from-to)834-840
Number of pages7
JournalJournal of Dental Research
Volume91
Issue number9
DOIs
StatePublished - Sep 2012

Fingerprint

Streptococcus mutans
HIV Infections
Genotype
HIV
Highly Active Antiretroviral Therapy
Viral Load
CD4 Lymphocyte Count
Saliva
Mouth
Tooth
Cell Count
T-Lymphocytes

Keywords

  • CD8+ T-lymphocytes
  • genotype
  • HAART
  • HIV infections
  • saliva
  • Streptococcus mutans

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

HIV infection affects streptococcus mutans levels, but not genotypes. / Liu, G.; Saxena, Deepak; Chen, Z.; Norman, R. G.; Phelan, J. A.; Laverty, M.; Fisch, G. S.; Corby, P. M.; Abrams, W.; Malamud, Daniel; Li, Yihong.

In: Journal of Dental Research, Vol. 91, No. 9, 09.2012, p. 834-840.

Research output: Contribution to journalArticle

Liu, G, Saxena, D, Chen, Z, Norman, RG, Phelan, JA, Laverty, M, Fisch, GS, Corby, PM, Abrams, W, Malamud, D & Li, Y 2012, 'HIV infection affects streptococcus mutans levels, but not genotypes', Journal of Dental Research, vol. 91, no. 9, pp. 834-840. https://doi.org/10.1177/0022034512454298
Liu, G. ; Saxena, Deepak ; Chen, Z. ; Norman, R. G. ; Phelan, J. A. ; Laverty, M. ; Fisch, G. S. ; Corby, P. M. ; Abrams, W. ; Malamud, Daniel ; Li, Yihong. / HIV infection affects streptococcus mutans levels, but not genotypes. In: Journal of Dental Research. 2012 ; Vol. 91, No. 9. pp. 834-840.
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