HIV-2 infection in an American

T. R. O'Brien, C. Polon, C. A. Schable, N. VanDevanter, M. A. Rayfield, D. Wallace, A. Stuart, S. D. Holmberg

Research output: Contribution to journalArticle


HIV-2 is endemic in West Africa but rare elsewhere. In the USA there have been 18 reported cases of HIV-2 infection; most identified people have been West Africans. We recently diagnosed the first case of HIV-2 infection in a native-born US citizen, a woman whose serum was found to be reactive to anti-HIV-1 enzyme immunoassay (EIA) when she attempted to donate blood in 1986. Although both HIV-1- and HIV-2-specific EIAs were reactive, the anti-HIV-2 Western blot (WB) was positive, while the anti-HIV-1 WB was positive or indeterminate on different occasions. Synthetic peptide testing was reactive for HIV-2 but not HIV-1. HIV-2 DNA was detected using the polymerase chain reaction procedure. Although she had travelled to West Africa, it is unclear how she became infected with HIV-2.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
Issue number1
StatePublished - Jan 1 1991



  • AIDS
  • HIV-2
  • United States
  • epidemiology
  • surveillance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

O'Brien, T. R., Polon, C., Schable, C. A., VanDevanter, N., Rayfield, M. A., Wallace, D., Stuart, A., & Holmberg, S. D. (1991). HIV-2 infection in an American. AIDS, 5(1), 85-88.