Abstract
Understanding how transcription factor (TF) binding is related to gene regulation is a moving target. We recently uncovered genome-wide evidence for a Hit-and-Run model of transcription. In this model, a master TF hits a target promoter to initiate a rapid response to a signal. As the hit is transient, the model invokes recruitment of partner TFs to sustain transcription over time. Following the run, the master TF hits other targets to propagate the response genome-wide. As such, a TF may act as a catalyst to mount a broad and acute response in cells that first sense the signal, while the recruited TF partners promote long-term adaptive behavior in the whole organism. This Hit-and-Run model likely has broad relevance, as TF perturbation studies across eukaryotes show small overlaps between TF-regulated and TF-bound genes, implicating transient TF-target binding. Here, we explore this Hit-and-Run model to suggest molecular mechanisms and its biological relevance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 851-856 |
| Number of pages | 6 |
| Journal | BioEssays |
| Volume | 37 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2015 |
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Keywords
- "Hit-and-Run"
- Dynamic regulation
- Gene regulatory networks
- TF binding
- Transcriptional model
- Transcriptional regulation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Hit-and-Run leaves its mark : Catalyst transcription factors and chromatin modification. / Varala, Kranthi; Li, Ying; Marshall-Colón, Amy; Para, Alessia; Coruzzi, Gloria M.
In: BioEssays, Vol. 37, No. 8, 01.08.2015, p. 851-856.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hit-and-Run leaves its mark
T2 - Catalyst transcription factors and chromatin modification
AU - Varala, Kranthi
AU - Li, Ying
AU - Marshall-Colón, Amy
AU - Para, Alessia
AU - Coruzzi, Gloria M.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Understanding how transcription factor (TF) binding is related to gene regulation is a moving target. We recently uncovered genome-wide evidence for a Hit-and-Run model of transcription. In this model, a master TF hits a target promoter to initiate a rapid response to a signal. As the hit is transient, the model invokes recruitment of partner TFs to sustain transcription over time. Following the run, the master TF hits other targets to propagate the response genome-wide. As such, a TF may act as a catalyst to mount a broad and acute response in cells that first sense the signal, while the recruited TF partners promote long-term adaptive behavior in the whole organism. This Hit-and-Run model likely has broad relevance, as TF perturbation studies across eukaryotes show small overlaps between TF-regulated and TF-bound genes, implicating transient TF-target binding. Here, we explore this Hit-and-Run model to suggest molecular mechanisms and its biological relevance.
AB - Understanding how transcription factor (TF) binding is related to gene regulation is a moving target. We recently uncovered genome-wide evidence for a Hit-and-Run model of transcription. In this model, a master TF hits a target promoter to initiate a rapid response to a signal. As the hit is transient, the model invokes recruitment of partner TFs to sustain transcription over time. Following the run, the master TF hits other targets to propagate the response genome-wide. As such, a TF may act as a catalyst to mount a broad and acute response in cells that first sense the signal, while the recruited TF partners promote long-term adaptive behavior in the whole organism. This Hit-and-Run model likely has broad relevance, as TF perturbation studies across eukaryotes show small overlaps between TF-regulated and TF-bound genes, implicating transient TF-target binding. Here, we explore this Hit-and-Run model to suggest molecular mechanisms and its biological relevance.
KW - "Hit-and-Run"
KW - Dynamic regulation
KW - Gene regulatory networks
KW - TF binding
KW - Transcriptional model
KW - Transcriptional regulation
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UR - http://www.scopus.com/inward/citedby.url?scp=84937523972&partnerID=8YFLogxK
U2 - 10.1002/bies.201400205
DO - 10.1002/bies.201400205
M3 - Article
C2 - 26108710
AN - SCOPUS:84937523972
VL - 37
SP - 851
EP - 856
JO - BioEssays
JF - BioEssays
SN - 0265-9247
IS - 8
ER -