Histologic study of a human immature permanent premolar with chronic apical abscess after revascularization/revitalization

Patricia Becerra, Domenico Ricucci, Simona Loghin, Jennifer Gibbs, Louis Lin

Research output: Contribution to journalArticle

Abstract

Introduction Histologic studies of teeth from animal models of revascularization/revitalization are available; however, specimens from human studies are lacking. The nature of tissues formed in the canal of human revascularized/revitalized teeth was not well established. Methods An immature mandibular premolar with infected necrotic pulp and a chronic apical abscess was treated with revascularization/revitalization procedures. At both the 18-month and 2-year follow-up visits, radiographic examination showed complete resolution of the periapical lesion, narrowing of the root apex without root lengthening, and minimal thickening of the canal walls. The revascularized/revitalized tooth was removed because of orthodontic treatment and processed for histologic examination. Results The large canal space of revascularized/revitalized tooth was not empty and filled with fibrous connective tissue. The apical closure was caused by cementum deposition without dentin. Some cementum-like tissue was formed on the canal dentin walls. Inflammatory cells were observed in the coronal and middle third of revascularized/revitalized tissue. Conclusions In the present case, the tissue formed in the canal of a human revascularized/ revitalized tooth was soft connective tissue similar to that in the periodontal ligament and cementum-like or bone-like hard tissue, which is comparable with the histology observed in the canals of teeth from animal models of revascularization/revitalization.

Original languageEnglish (US)
Pages (from-to)133-139
Number of pages7
JournalJournal of Endodontics
Volume40
Issue number1
DOIs
StatePublished - Jan 2014

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Bicuspid
Abscess
Tooth
Dental Cementum
Dentin
Connective Tissue
Animal Models
Periodontal Ligament
Orthodontics
Histology
Bone and Bones

Keywords

  • Bone-like tissue
  • cementum-like tissue
  • chronic apical abscess
  • human immature permanent tooth
  • revascularization/revitalization

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Histologic study of a human immature permanent premolar with chronic apical abscess after revascularization/revitalization. / Becerra, Patricia; Ricucci, Domenico; Loghin, Simona; Gibbs, Jennifer; Lin, Louis.

In: Journal of Endodontics, Vol. 40, No. 1, 01.2014, p. 133-139.

Research output: Contribution to journalArticle

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