Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning

Marta A P Moita, Svetlana Rosis, Yu Zhou, Joseph Ledoux, Hugh T. Blair

Research output: Contribution to journalArticle

Abstract

We recorded neurons from the hippocampus of freely behaving rats during an auditory fear conditioning task. Rats received either paired or unpaired presentations of an auditory conditioned stimulus (CS) and an electric shock unconditioned stimulus (US). Hippocampal neurons (place and theta cells) acquired responses to the auditory CS in the paired but not in the unpaired group. After CS-US pairing, rhythmic firing of theta cells became synchronized to the onset of the CS. Conditioned responses of place cells were gated by their location-specific firing, so that after CS-US pairing, place cells responded to the CS only when the rat was within the cell's place field. These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning.

Original languageEnglish (US)
Pages (from-to)485-497
Number of pages13
JournalNeuron
Volume37
Issue number3
DOIs
StatePublished - Feb 6 2003

Fingerprint

Fear
Hippocampus
Neurons
Shock
Learning
Conditioning (Psychology)
Place Cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning. / Moita, Marta A P; Rosis, Svetlana; Zhou, Yu; Ledoux, Joseph; Blair, Hugh T.

In: Neuron, Vol. 37, No. 3, 06.02.2003, p. 485-497.

Research output: Contribution to journalArticle

Moita, Marta A P ; Rosis, Svetlana ; Zhou, Yu ; Ledoux, Joseph ; Blair, Hugh T. / Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning. In: Neuron. 2003 ; Vol. 37, No. 3. pp. 485-497.
@article{aa4c9feaffc143adbb9754b03be5d604,
title = "Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning",
abstract = "We recorded neurons from the hippocampus of freely behaving rats during an auditory fear conditioning task. Rats received either paired or unpaired presentations of an auditory conditioned stimulus (CS) and an electric shock unconditioned stimulus (US). Hippocampal neurons (place and theta cells) acquired responses to the auditory CS in the paired but not in the unpaired group. After CS-US pairing, rhythmic firing of theta cells became synchronized to the onset of the CS. Conditioned responses of place cells were gated by their location-specific firing, so that after CS-US pairing, place cells responded to the CS only when the rat was within the cell's place field. These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning.",
author = "Moita, {Marta A P} and Svetlana Rosis and Yu Zhou and Joseph Ledoux and Blair, {Hugh T.}",
year = "2003",
month = "2",
day = "6",
doi = "10.1016/S0896-6273(03)00033-3",
language = "English (US)",
volume = "37",
pages = "485--497",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning

AU - Moita, Marta A P

AU - Rosis, Svetlana

AU - Zhou, Yu

AU - Ledoux, Joseph

AU - Blair, Hugh T.

PY - 2003/2/6

Y1 - 2003/2/6

N2 - We recorded neurons from the hippocampus of freely behaving rats during an auditory fear conditioning task. Rats received either paired or unpaired presentations of an auditory conditioned stimulus (CS) and an electric shock unconditioned stimulus (US). Hippocampal neurons (place and theta cells) acquired responses to the auditory CS in the paired but not in the unpaired group. After CS-US pairing, rhythmic firing of theta cells became synchronized to the onset of the CS. Conditioned responses of place cells were gated by their location-specific firing, so that after CS-US pairing, place cells responded to the CS only when the rat was within the cell's place field. These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning.

AB - We recorded neurons from the hippocampus of freely behaving rats during an auditory fear conditioning task. Rats received either paired or unpaired presentations of an auditory conditioned stimulus (CS) and an electric shock unconditioned stimulus (US). Hippocampal neurons (place and theta cells) acquired responses to the auditory CS in the paired but not in the unpaired group. After CS-US pairing, rhythmic firing of theta cells became synchronized to the onset of the CS. Conditioned responses of place cells were gated by their location-specific firing, so that after CS-US pairing, place cells responded to the CS only when the rat was within the cell's place field. These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning.

UR - http://www.scopus.com/inward/record.url?scp=0037421623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037421623&partnerID=8YFLogxK

U2 - 10.1016/S0896-6273(03)00033-3

DO - 10.1016/S0896-6273(03)00033-3

M3 - Article

VL - 37

SP - 485

EP - 497

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 3

ER -