Hippocampal memory and plasticity in superoxide dismutase mutant mice

Edda Thiels, Eric Klann

Research output: Contribution to journalArticle

Abstract

The reactive oxygen species (ROS) superoxide is well known for its role in disease mechanisms. Mounting evidence indicates, however, that superoxide also is generated for useful purposes and contributes to normal physiologic function. Studies with transgenic mice that overexpress superoxide scavengers show that certain types of memory function and underlying neuronal processes are impaired under conditions of severely reduced superoxide signaling. These findings have implications for the use of antioxidant treatments as well as for our understanding of the signaling events involved in cognition.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalPhysiology and Behavior
Volume77
Issue number4-5
DOIs
StatePublished - Dec 2002

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Keywords

  • Associative memory
  • Contextual fear conditioning
  • Hippocampus
  • Long-term potentiation
  • Reactive oxygen species
  • Superoxide
  • Superoxide dismutase
  • Synaptic plasticity

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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