Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase

Daoying Hu, Peng Cao, Edda Thiels, Charleen T. Chu, Gang yi Wu, Tim D. Oury, Eric Klann

Research output: Contribution to journalArticle

Abstract

Superoxide has been shown to be critically involved in several pathological manifestations of aging animals. In contrast, superoxide also can act as a signaling molecule to modulate signal transduction cascades required for hippocampal synaptic plasticity. Mitochondrial superoxide dismutase (SOD-2 or Mn-SOD) is a key antioxidant enzyme that scavenges superoxide. Thus, SOD-2 may not only prevent aging-related oxidative stress, but may also regulate redox signaling in young animals. We used transgenic mice overexpressing SOD-2 to study the role of mitochondrial superoxide in aging, synaptic plasticity, and memory-associated behavior. We found that overexpression of SOD-2 had no obvious effect on synaptic plasticity and memory formation in young mice, and could not rescue the age-related impairments in either synaptic plasticity or memory in old mice. However, SOD-2 overexpression did decrease mitochondrial superoxide in hippocampal neurons, and extended the lifespan of the mice. These findings increase our knowledge of the role of mitochondrial superoxide in physiological and pathological processes in the brain.

Original languageEnglish (US)
Pages (from-to)372-384
Number of pages13
JournalNeurobiology of Learning and Memory
Volume87
Issue number3
DOIs
StatePublished - Mar 2007

Fingerprint

Long-Term Memory
Long-Term Potentiation
Superoxides
Superoxide Dismutase
Neuronal Plasticity
Physiological Phenomena
Pathologic Processes
Transgenic Mice
Oxidation-Reduction
Signal Transduction
Oxidative Stress
Antioxidants
Neurons
Brain
Enzymes

Keywords

  • Aging
  • Antioxidant
  • Learning and memory
  • Reactive oxygen species
  • Synaptic plasticity

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. / Hu, Daoying; Cao, Peng; Thiels, Edda; Chu, Charleen T.; Wu, Gang yi; Oury, Tim D.; Klann, Eric.

In: Neurobiology of Learning and Memory, Vol. 87, No. 3, 03.2007, p. 372-384.

Research output: Contribution to journalArticle

Hu, Daoying ; Cao, Peng ; Thiels, Edda ; Chu, Charleen T. ; Wu, Gang yi ; Oury, Tim D. ; Klann, Eric. / Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. In: Neurobiology of Learning and Memory. 2007 ; Vol. 87, No. 3. pp. 372-384.
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