HippDB

A database of readily targeted helical protein-protein interactions

Christina M. Bergey, Andrew M. Watkins, Paramjit Arora

Research output: Contribution to journalArticle

Abstract

Summary: HippDB catalogs every protein-protein interaction whose structure is available in the Protein Data Bank and which exhibits one or more helices at the interface. The Web site accepts queries on variables such as helix length and sequence, and it provides computational alanine scanning and change in solvent-accessible surface area values for every interfacial residue. HippDB is intended to serve as a starting point for structure-based small molecule and peptidomimetic drug development. Availability and implementation: HippDB is freely available on the web at http://www.nyu.edu/projects/arora/hippdb. The Web site is implemented in PHP, MySQL and Apache. Source code freely available for download at http://code.google.com/p/helidb, implemented in Perl and supported on Linux.

Original languageEnglish (US)
Pages (from-to)2806-2807
Number of pages2
JournalBioinformatics
Volume29
Issue number21
DOIs
StatePublished - Nov 1 2013

Fingerprint

Protein-protein Interaction
Databases
Helix
Proteins
Websites
Peptidomimetics
Linux
Surface area
Alanine
Scanning
Drugs
Availability
Molecules
Query
Protein
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Computational Mathematics
  • Statistics and Probability
  • Medicine(all)

Cite this

HippDB : A database of readily targeted helical protein-protein interactions. / Bergey, Christina M.; Watkins, Andrew M.; Arora, Paramjit.

In: Bioinformatics, Vol. 29, No. 21, 01.11.2013, p. 2806-2807.

Research output: Contribution to journalArticle

Bergey, Christina M. ; Watkins, Andrew M. ; Arora, Paramjit. / HippDB : A database of readily targeted helical protein-protein interactions. In: Bioinformatics. 2013 ; Vol. 29, No. 21. pp. 2806-2807.
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