Highly porous crosslinkable PLA-PNB block copolymer scaffolds

Yiqing Wang, David E. Noga, Kunsang Yoon, Abigail M. Wojtowicz, Angela S P Lin, Andrés J. García, David M. Collard, Marcus Weck

Research output: Contribution to journalArticle

Abstract

Poly(lactic acid) (PLA)-block-poly(norbornene) (PNB) copolymers which bear photocrosslinkable cinnamate side-chains are synthesized by combining the ring-opening metathesis polymerization (ROMP) of norbornenes with the ring-opening polymerization (ROP) of lactides. Highly porous 3D scaffolds with tunable pore sizes ranging from 20 to 300 μm are fabricated through liquid-solid phase separation. Scaffolds with an average pore size around 250 μm, which are under investigation as bone grafting materials, are reproducibly obtained from freeze-drying 5% w/v benzene solutions of PLA-b-PNB copolymers at -10°C. As a demonstration of the impact of photocrosslinking of cinnamate side-chains, scaffolds are exposed to UV radiation for 8h, resulting in a 33% increase in the compressive modulus of the polymeric scaffold. The foams and the methodology described herein represent a new strategy toward polymeric scaffolds with potential for use in regenerative medicine applications.

Original languageEnglish (US)
Pages (from-to)3638-3644
Number of pages7
JournalAdvanced Functional Materials
Volume18
Issue number22
DOIs
StatePublished - Nov 24 2008

Fingerprint

block copolymers
Scaffolds
Block copolymers
copolymers
polymerization
porosity
freeze drying
lactic acid
Cinnamates
metathesis
rings
bears
medicine
foams
bones
Ring opening polymerization
solid phases
benzene
Pore size
methodology

ASJC Scopus subject areas

  • Biomaterials
  • Electrochemistry
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Wang, Y., Noga, D. E., Yoon, K., Wojtowicz, A. M., Lin, A. S. P., García, A. J., ... Weck, M. (2008). Highly porous crosslinkable PLA-PNB block copolymer scaffolds. Advanced Functional Materials, 18(22), 3638-3644. https://doi.org/10.1002/adfm.200800385

Highly porous crosslinkable PLA-PNB block copolymer scaffolds. / Wang, Yiqing; Noga, David E.; Yoon, Kunsang; Wojtowicz, Abigail M.; Lin, Angela S P; García, Andrés J.; Collard, David M.; Weck, Marcus.

In: Advanced Functional Materials, Vol. 18, No. 22, 24.11.2008, p. 3638-3644.

Research output: Contribution to journalArticle

Wang, Y, Noga, DE, Yoon, K, Wojtowicz, AM, Lin, ASP, García, AJ, Collard, DM & Weck, M 2008, 'Highly porous crosslinkable PLA-PNB block copolymer scaffolds', Advanced Functional Materials, vol. 18, no. 22, pp. 3638-3644. https://doi.org/10.1002/adfm.200800385
Wang Y, Noga DE, Yoon K, Wojtowicz AM, Lin ASP, García AJ et al. Highly porous crosslinkable PLA-PNB block copolymer scaffolds. Advanced Functional Materials. 2008 Nov 24;18(22):3638-3644. https://doi.org/10.1002/adfm.200800385
Wang, Yiqing ; Noga, David E. ; Yoon, Kunsang ; Wojtowicz, Abigail M. ; Lin, Angela S P ; García, Andrés J. ; Collard, David M. ; Weck, Marcus. / Highly porous crosslinkable PLA-PNB block copolymer scaffolds. In: Advanced Functional Materials. 2008 ; Vol. 18, No. 22. pp. 3638-3644.
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