Highly porous crosslinkable PLA-PNB block copolymer scaffolds

Yiqing Wang, David E. Noga, Kunsang Yoon, Abigail M. Wojtowicz, Angela S.P. Lin, Andrés J. García, David M. Collard, Marcus Weck

Research output: Contribution to journalArticle

Abstract

Poly(lactic acid) (PLA)-block-poly(norbornene) (PNB) copolymers which bear photocrosslinkable cinnamate side-chains are synthesized by combining the ring-opening metathesis polymerization (ROMP) of norbornenes with the ring-opening polymerization (ROP) of lactides. Highly porous 3D scaffolds with tunable pore sizes ranging from 20 to 300 μm are fabricated through liquid-solid phase separation. Scaffolds with an average pore size around 250 μm, which are under investigation as bone grafting materials, are reproducibly obtained from freeze-drying 5% w/v benzene solutions of PLA-b-PNB copolymers at -10°C. As a demonstration of the impact of photocrosslinking of cinnamate side-chains, scaffolds are exposed to UV radiation for 8h, resulting in a 33% increase in the compressive modulus of the polymeric scaffold. The foams and the methodology described herein represent a new strategy toward polymeric scaffolds with potential for use in regenerative medicine applications.

Original languageEnglish (US)
Pages (from-to)3638-3644
Number of pages7
JournalAdvanced Functional Materials
Volume18
Issue number22
DOIs
StatePublished - Nov 24 2008

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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  • Cite this

    Wang, Y., Noga, D. E., Yoon, K., Wojtowicz, A. M., Lin, A. S. P., García, A. J., Collard, D. M., & Weck, M. (2008). Highly porous crosslinkable PLA-PNB block copolymer scaffolds. Advanced Functional Materials, 18(22), 3638-3644. https://doi.org/10.1002/adfm.200800385