High throughput RESS processing of sub-10 nm ibuprofen nanoparticles

Sudhir Kumar Sharma, Ramesh Jagannathan

Research output: Contribution to journalArticle

Abstract

We report the results of our research on the RESS precipitation of molecular clusters of ibuprofen with four different surfactants and the effect of surfactant concentration on their size. Our custom designed, liquid N2 cooled collection process of the molecular clusters embedded in "dry ice", resulted in yields of up to 80% (w/w). Sublimation of the 'dry ice' in deionized water resulted in dispersions of ibuprofen in water. These dispersions were found to be stable at room temperature, for up to six months, as confirmed by DLS and AFM characterizations. Solution casting of the dispersions on silicon and sapphire substrates resulted in high quality, "liquid like" viscous films as observed by optical microscopy and AFM. XRD and confocal Raman characterizations confirmed that the molecular clusters retained their chemical identity of ibuprofen. Besides its scientific importance, this invention is expected to open up new drug delivery platforms.

Original languageEnglish (US)
Pages (from-to)74-79
Number of pages6
JournalJournal of Supercritical Fluids
Volume109
DOIs
StatePublished - Mar 1 2016

Fingerprint

molecular clusters
Ibuprofen
Dry Ice
Dispersions
Throughput
Nanoparticles
Surface-Active Agents
nanoparticles
Ice
ice
Surface active agents
Processing
surfactants
atomic force microscopy
inventions
Aluminum Oxide
Deionized water
Sublimation
Liquids
Patents and inventions

Keywords

  • Drug nanoparticles
  • Hydrophobicity
  • Ibuprofen
  • Micronization
  • RESS
  • Supercritical fluids

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

High throughput RESS processing of sub-10 nm ibuprofen nanoparticles. / Sharma, Sudhir Kumar; Jagannathan, Ramesh.

In: Journal of Supercritical Fluids, Vol. 109, 01.03.2016, p. 74-79.

Research output: Contribution to journalArticle

@article{0db0f6c8fa8f431d9b6a5cc19d0334fb,
title = "High throughput RESS processing of sub-10 nm ibuprofen nanoparticles",
abstract = "We report the results of our research on the RESS precipitation of molecular clusters of ibuprofen with four different surfactants and the effect of surfactant concentration on their size. Our custom designed, liquid N2 cooled collection process of the molecular clusters embedded in {"}dry ice{"}, resulted in yields of up to 80{\%} (w/w). Sublimation of the 'dry ice' in deionized water resulted in dispersions of ibuprofen in water. These dispersions were found to be stable at room temperature, for up to six months, as confirmed by DLS and AFM characterizations. Solution casting of the dispersions on silicon and sapphire substrates resulted in high quality, {"}liquid like{"} viscous films as observed by optical microscopy and AFM. XRD and confocal Raman characterizations confirmed that the molecular clusters retained their chemical identity of ibuprofen. Besides its scientific importance, this invention is expected to open up new drug delivery platforms.",
keywords = "Drug nanoparticles, Hydrophobicity, Ibuprofen, Micronization, RESS, Supercritical fluids",
author = "Sharma, {Sudhir Kumar} and Ramesh Jagannathan",
year = "2016",
month = "3",
day = "1",
doi = "10.1016/j.supflu.2015.11.019",
language = "English (US)",
volume = "109",
pages = "74--79",
journal = "Journal of Supercritical Fluids",
issn = "0896-8446",
publisher = "Elsevier",

}

TY - JOUR

T1 - High throughput RESS processing of sub-10 nm ibuprofen nanoparticles

AU - Sharma, Sudhir Kumar

AU - Jagannathan, Ramesh

PY - 2016/3/1

Y1 - 2016/3/1

N2 - We report the results of our research on the RESS precipitation of molecular clusters of ibuprofen with four different surfactants and the effect of surfactant concentration on their size. Our custom designed, liquid N2 cooled collection process of the molecular clusters embedded in "dry ice", resulted in yields of up to 80% (w/w). Sublimation of the 'dry ice' in deionized water resulted in dispersions of ibuprofen in water. These dispersions were found to be stable at room temperature, for up to six months, as confirmed by DLS and AFM characterizations. Solution casting of the dispersions on silicon and sapphire substrates resulted in high quality, "liquid like" viscous films as observed by optical microscopy and AFM. XRD and confocal Raman characterizations confirmed that the molecular clusters retained their chemical identity of ibuprofen. Besides its scientific importance, this invention is expected to open up new drug delivery platforms.

AB - We report the results of our research on the RESS precipitation of molecular clusters of ibuprofen with four different surfactants and the effect of surfactant concentration on their size. Our custom designed, liquid N2 cooled collection process of the molecular clusters embedded in "dry ice", resulted in yields of up to 80% (w/w). Sublimation of the 'dry ice' in deionized water resulted in dispersions of ibuprofen in water. These dispersions were found to be stable at room temperature, for up to six months, as confirmed by DLS and AFM characterizations. Solution casting of the dispersions on silicon and sapphire substrates resulted in high quality, "liquid like" viscous films as observed by optical microscopy and AFM. XRD and confocal Raman characterizations confirmed that the molecular clusters retained their chemical identity of ibuprofen. Besides its scientific importance, this invention is expected to open up new drug delivery platforms.

KW - Drug nanoparticles

KW - Hydrophobicity

KW - Ibuprofen

KW - Micronization

KW - RESS

KW - Supercritical fluids

UR - http://www.scopus.com/inward/record.url?scp=84948766621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948766621&partnerID=8YFLogxK

U2 - 10.1016/j.supflu.2015.11.019

DO - 10.1016/j.supflu.2015.11.019

M3 - Article

AN - SCOPUS:84948766621

VL - 109

SP - 74

EP - 79

JO - Journal of Supercritical Fluids

JF - Journal of Supercritical Fluids

SN - 0896-8446

ER -